2. Gene
  3. Appl1 - adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 Gene

Appl1 - adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as RGD1309388

Gene ID: 290537 | Gene type: protein coding

About Appl1

Summary

Predicted to enable several functions, including beta-tubulin binding activity; phospholipid binding activity; and protein homodimerization activity. Predicted to be involved in several processes, including cell surface receptor signaling pathway; cellular response to hepatocyte growth factor stimulus; and regulation of vesicle-mediated transport. Predicted to be located in several cellular components, including cytoplasmic vesicle; ruffle; and vesicle membrane. Predicted to be active in endosome membrane. Human ortholog(s) of this gene implicated in maturity-onset diabetes of the young type 14. Orthologous to human APPL1 (adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1). [provided by Alliance of Genome Resources, Apr 2022]

Appl1 Products(1)

mRNA Protein Name
NM_001399084.1 NP_001386013.1 adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1
Gene Ontology
  • Molecular Function
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
17848569 RGD
Cellular Component GO Annotation Evidence Reference Source
is active in postsynapse IDA
IDA: Inferred from direct assay
21236345 RGD
is active in presynapse IDA
IDA: Inferred from direct assay
21236345 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

DCC-interacting protein 13-alpha

adaptor protein, phosphotyrosine interacting with PH domain and leucine zipper 1

adaptor protein, phosphotyrosine interaction, PH domain and leucine zipper containing 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS00867 APPL1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS20366 Appl1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS26876 Appl1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Appl1 NCBI NCBI:26060