2. Gene
  3. Cr2 - complement C3d receptor 2 Gene

Cr2 - complement C3d receptor 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as Cd21

Gene ID: 289395 | Gene type: protein coding

About Cr2

Summary

Predicted to enable several functions, including complement binding activity; Complement Receptor activity; and protein homodimerization activity. Predicted to be involved in B cell differentiation; B cell proliferation; and negative regulation of complement activation, classical pathway. Predicted to act upstream of or within with a negative effect on complement activation, alternative pathway. Predicted to act upstream of or within several processes, including cellular response to lipopolysaccharide; immunoglobulin mediated immune response; and skeletal system development. Located in several cellular components, including cell surface; extracellular space; and nucleus. Human ortholog(s) of this gene implicated in common variable immunodeficiency; nasopharynx carcinoma; and systemic lupus erythematosus. Orthologous to human CR2 (complement C3d receptor 2). [provided by Alliance of Genome Resources, Apr 2022]

Cr2 Products(1)

mRNA Protein Name
NM_001105989.2 NP_001099459.2 complement receptor type 2 precursor
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in cell surface IDA
IDA: Inferred from direct assay
12008031 RGD
located in extracellular space IDA
IDA: Inferred from direct assay
26502875 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

complement receptor type 2

complement component (3d/Epstein Barr virus) receptor 2

complement component 3d receptor 2

complement receptor 2

Related Agents

Pre-clinical Phase
Bioactive Molecules (8)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-NP137 NP-PE (Phycoerythrin) / Unkown
HY-RS11487 PYCR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-N12760 Lobophorin CR-2 / Unkown
HY-RS03133 CR2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS13960 STRADB Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS15728 VWA5A Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18588 Cr2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25073 Cr2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Cr2 NCBI NCBI:1380
Canis familiaris Cr2 NCBI
Macaca fascicularis Cr2 NCBI NCBI:102145559
Mus musculus Cr2 NCBI NCBI:12902
Macaca mulatta Cr2 NCBI NCBI:714202