2. Gene
  3. Ncstn - nicastrin Gene

Ncstn - nicastrin Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 289231 | Gene type: protein coding

About Ncstn

Summary

Enables peptidase activity. Involved in cerebellum development and protein processing. Located in several cellular components, including cytoplasmic vesicle; lysosomal membrane; and sarcolemma. Part of protein-containing complex. Is integral component of presynaptic membrane. Human ortholog(s) of this gene implicated in Alzheimer's disease; hidradenitis suppurativa; and schizophrenia. Orthologous to human NCSTN (nicastrin). [provided by Alliance of Genome Resources, Apr 2022]

Ncstn Products(1)

mRNA Protein Name
NM_174864.3 NP_777353.1 nicastrin precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables peptidase activity IDA
IDA: Inferred from direct assay
12736250 RGD
enables protein binding IPI
IPI: Inferred from physical interaction
15456764 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cerebellum development IEP
IEP: Inferred from expression pattern
16298244 RGD
involved in protein processing IEP
IEP: Inferred from expression pattern
12736250 RGD
Cellular Component GO Annotation Evidence Reference Source
located in early endosome IDA
IDA: Inferred from direct assay
20126630 RGD
located in lysosomal membrane IDA
IDA: Inferred from direct assay
12736250 RGD
is active in presynaptic membrane IDA
IDA: Inferred from direct assay
20126630 RGD
part of protein-containing complex IDA
IDA: Inferred from direct assay
15456764 RGD
located in sarcolemma IDA
IDA: Inferred from direct assay
16595164 RGD
located in synaptic membrane IDA
IDA: Inferred from direct assay
20126630 RGD
located in synaptic vesicle IDA
IDA: Inferred from direct assay
20126630 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

nicastrin

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09103 NCSTN Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18670 Ncstn Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25156 Ncstn Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ncstn NCBI NCBI:23385
Mus musculus Ncstn NCBI NCBI:59287