Fis1 - fission, mitochondrial 1 Gene

Rattus norvegicus

Also known as Ttc11

Gene ID: 288584 | Gene type: protein coding

About Fis1

Summary

Enables identical protein binding activity. Involved in several processes, including cellular response to thapsigargin; mitochondrial fragmentation involved in apoptotic process; and positive regulation of mitochondrial fission. Located in mitochondrion and peroxisomal membrane. Is integral component of mitochondrial outer membrane. Biomarker of dental fluorosis; fatty liver disease; kidney failure (multiple); myocardial infarction; and rhinitis. Orthologous to human FIS1 (fission, mitochondrial 1). [provided by Alliance of Genome Resources, Apr 2022]

Fis1 Products(2)

mRNA	Protein	Name
NM_001105919.2	NP_001099389.1	mitochondrial fission 1 protein isoform 1
NM_001401051.1	NP_001387980.1	mitochondrial fission 1 protein isoform 2

Gene Ontology

Biological Process
Cellular Component

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	27684054	RGD
involved in cellular response to lipid	IEP IEP: Inferred from expression pattern	18006463	RGD
involved in cellular response to peptide	IDA IDA: Inferred from direct assay	24103571	RGD
involved in cellular response to toxic substance	IEP IEP: Inferred from expression pattern	26732598	RGD
involved in mitochondrial fragmentation involved in apoptotic process	IMP IMP: Inferred from mutant phenotype	18940801	RGD
involved in positive regulation of mitochondrial fission	IMP IMP: Inferred from mutant phenotype	15979461	RGD
involved in positive regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	18940801	RGD
involved in response to endoplasmic reticulum stress	IMP IMP: Inferred from mutant phenotype	17443673	RGD
involved in response to flavonoid	IEP IEP: Inferred from expression pattern	24637344	RGD
involved in response to fluoride	IEP IEP: Inferred from expression pattern	23007560	RGD
involved in response to hypobaric hypoxia	IEP IEP: Inferred from expression pattern	24361501	RGD
involved in response to muscle activity	IEP IEP: Inferred from expression pattern	24943897	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	25336449	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	15979461	RGD
located in peroxisomal membrane	IDA IDA: Inferred from direct assay	16107562	RGD
located in peroxisome	IDA IDA: Inferred from direct assay	14561759	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

mitochondrial fission 1 protein

TPR repeat protein 11	fis1 homolog
fission 1 (mitochondrial outer membrane) homolog	rFis1
tetratricopeptide repeat domain 11	tetratricopeptide repeat protein 11

Related Agents

Pre-clinical Phase

Bioactive Molecules (7)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P10368	P110 heptapeptide	Inhibitor	99.84%	Unkown
HY-P2280	TAT-P110	Inhibitor	99.87%	Unkown
HY-155656	Anti-inflammatory agent 49	Inhibitor	98.26%	Unkown
HY-RS04951	FIS1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-172942	SP11	Inhibitor	/	Unkown
HY-RS19331	Fis1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25822	Fis1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fis1	NCBI	NCBI:51024

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