Per1 - period circadian regulator 1 Gene

Rattus norvegicus

Also known as rper1

Gene ID: 287422 | Gene type: protein coding

About Per1

Summary

This gene is a member of the Period family of genes and is expressed in a circadian pattern in the suprachiasmatic nucleus, the primary circadian pacemaker in the mammalian brain. Genes in this family encode components of the circadian rhythms of locomotor activity, metabolism, and behavior. This gene is upregulated by Clock/Arntl heterodimers but then represses this upregulation in a feedback loop using Per/Cry heterodimers to interact with Clock/Arntl. Polymorphisms in this gene may increase the risk of getting certain cancers. [provided by RefSeq, Jan 2014]

Per1 Products(1)

mRNA	Protein	Name
NM_001034125.1	NP_001029297.1	period circadian protein homolog 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	11597585	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	12176169	RGD
involved in circadian rhythm	IMP IMP: Inferred from mutant phenotype	11122332	RGD
involved in negative regulation of JNK cascade	IMP IMP: Inferred from mutant phenotype	24447840	RGD
involved in negative regulation of canonical NF-kappaB signal transduction	IMP IMP: Inferred from mutant phenotype	24447840	RGD
involved in neural retina development	IEP IEP: Inferred from expression pattern	20589906	RGD
involved in regulation of cytokine production involved in inflammatory response	IMP IMP: Inferred from mutant phenotype	24447840	RGD
involved in regulation of p38MAPK cascade	IMP IMP: Inferred from mutant phenotype	24447840	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	22356123	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

period circadian protein homolog 1

circadian clock protein PERIOD 1	period 1
period circadian clock 1	period homolog 1

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-125145	AA92593		99.94%	Unkown
HY-N10987	Spiranthesol		/	Unkown
HY-RS10331	PER1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS19930	Per1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26432	Per1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Per1	NCBI	NCBI:5187

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