2. Gene
  3. Gm2a - ganglioside GM2 activator Gene

Gm2a - ganglioside GM2 activator Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 282838 | Gene type: protein coding

About Gm2a

Summary

Enables lipid transporter activity and Phospholipase activator activity. Contributes to beta-N-acetylgalactosaminidase activity. Involved in ganglioside metabolic process; lipid transport; and positive regulation of hydrolase activity. Located in several cellular components, including apical plasma membrane; basolateral plasma membrane; and cytoplasmic side of plasma membrane. Human ortholog(s) of this gene implicated in GM2 gangliosidosis and GM2 gangliosidosis, AB variant. Orthologous to human GM2A (GM2 ganglioside activator). [provided by Alliance of Genome Resources, Apr 2022]

Gm2a Products(1)

mRNA Protein Name
NM_172335.2 NP_758838.2 ganglioside GM2 activator precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
contributes to beta-N-acetylgalactosaminidase activity IDA
IDA: Inferred from direct assay
9770472 RGD
enables lipid transporter activity IDA
IDA: Inferred from direct assay
8948454 RGD
enables phospholipase activator activity IDA
IDA: Inferred from direct assay
9770472 RGD
Biological Process GO Annotation Evidence Reference Source
involved in ganglioside metabolic process IDA
IDA: Inferred from direct assay
9770472 RGD
involved in lipid transport IDA
IDA: Inferred from direct assay
8948454 RGD
NOT involved in membrane fusion IDA
IDA: Inferred from direct assay
8948454 RGD
involved in positive regulation of hydrolase activity IDA
IDA: Inferred from direct assay
9770472 RGD
Cellular Component GO Annotation Evidence Reference Source
located in apical plasma membrane IDA
IDA: Inferred from direct assay
10073593 RGD
located in basolateral plasma membrane IDA
IDA: Inferred from direct assay
10073593 RGD
located in cytoplasmic side of plasma membrane IDA
IDA: Inferred from direct assay
10073593 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

ganglioside GM2 activator

GM2 ganglioside activator protein

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS05513 GM2A Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18134 Gm2a Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24609 Gm2a Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Gm2a NCBI NCBI:2760