2. Gene
  3. Depdc5 - DEP domain containing 5 Gene

Depdc5 - DEP domain containing 5 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus
Gene ID: 277854 | Gene type: protein coding

About Depdc5

Summary

Predicted to contribute to GTPase activator activity. Predicted to be involved in cellular response to amino acid starvation; negative regulation of TORC1 signaling; and regulation of Autophagy. Located in cytosol and perinuclear region of cytoplasm. Is expressed in branchial arch; genitourinary system; limb; and peripheral nervous system. Human ortholog(s) of this gene implicated in focal epilepsy. Orthologous to human DEPDC5 (DEP domain containing 5, GATOR1 subcomplex subunit). [provided by Alliance of Genome Resources, Apr 2022]

Depdc5 Products(17)

mRNA Protein Name
NM_001025426.3 NP_001020597.1 GATOR complex protein DEPDC5 isoform 1
NM_001170567.2 NP_001164038.1 GATOR complex protein DEPDC5 isoform 3
NM_001360014.2 NP_001346943.1 GATOR complex protein DEPDC5 isoform 4
NM_001404313.1 NP_001391242.1 GATOR complex protein DEPDC5 isoform 3
NM_001404314.1 NP_001391243.1 GATOR complex protein DEPDC5 isoform 1
NM_001404315.1 NP_001391244.1 GATOR complex protein DEPDC5 isoform 5
NM_001404316.1 NP_001391245.1 GATOR complex protein DEPDC5 isoform 6
NM_001404317.1 NP_001391246.1 GATOR complex protein DEPDC5 isoform 6
NM_001404318.1 NP_001391247.1 GATOR complex protein DEPDC5 isoform 7
NM_001404319.1 NP_001391248.1 GATOR complex protein DEPDC5 isoform 8
NM_001404320.1 NP_001391249.1 GATOR complex protein DEPDC5 isoform 8
NM_001404332.1 NP_001391261.1 GATOR complex protein DEPDC5 isoform 9
NM_001404333.1 NP_001391262.1 GATOR complex protein DEPDC5 isoform 9
NM_001404334.1 NP_001391263.1 GATOR complex protein DEPDC5 isoform 10
NM_001404335.1 NP_001391264.1 GATOR complex protein DEPDC5 isoform 11
NM_001404336.1 NP_001391265.1 GATOR complex protein DEPDC5 isoform 11
NM_177786.5 NP_808454.2 GATOR complex protein DEPDC5 isoform 2
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in cytosol IDA
IDA: Inferred from direct assay
23542697 MGI
located in perinuclear region of cytoplasm IDA
IDA: Inferred from direct assay
23542697 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

GATOR complex protein DEPDC5

DEP domain-containing protein 5

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS03695 DEPDC5 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20545 Depdc5 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27054 Depdc5 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Depdc5 NCBI NCBI:9681