Amot - angiomotin Gene

Mus musculus

Also known as Sii6; CAG-2; D0Kist1

Gene ID: 27494 | Gene type: protein coding

About Amot

Summary

Predicted to enable angiostatin binding activity and signaling receptor activity. Acts upstream of or within several processes, including ameboidal-type cell migration; negative regulation of GTPase activity; and vasculogenesis. Located in bicellular tight junction; cytoplasmic vesicle; and lamellipodium. Is expressed in several structures, including egg cylinder; embryo endoderm; embryo mesoderm; and mesendoderm. Orthologous to human AMOT (angiomotin). [provided by Alliance of Genome Resources, Apr 2022]

Amot Products(6)

mRNA	Protein	Name
NM_001290274.2	NP_001277203.1	angiomotin isoform 2
NM_001403386.1	NP_001390315.1	angiomotin isoform 3
NM_001403387.1	NP_001390316.1	angiomotin isoform 1
NM_001403388.1	NP_001390317.1	angiomotin isoform 1
NM_001403389.1	NP_001390318.1	angiomotin isoform 3
NM_153319.4	NP_695231.3	angiomotin isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	17397395	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	17699752	MGI
acts upstream of or within blood vessel endothelial cell migration	IMP IMP: Inferred from mutant phenotype	17699752	MGI
acts upstream of or within blood vessel morphogenesis	IMP IMP: Inferred from mutant phenotype	17699752	MGI
acts upstream of or within cell migration involved in gastrulation	IMP IMP: Inferred from mutant phenotype	12676095	MGI
acts upstream of or within chemotaxis	IMP IMP: Inferred from mutant phenotype	12902404	MGI
acts upstream of embryo development	IMP IMP: Inferred from mutant phenotype	12676095	MGI
acts upstream of or within establishment of cell polarity involved in ameboidal cell migration	IMP IMP: Inferred from mutant phenotype	17699752	MGI
acts upstream of or within gastrulation with mouth forming second	IMP IMP: Inferred from mutant phenotype	12676095	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	12676095	MGI
acts upstream of or within negative regulation of GTPase activity	IMP IMP: Inferred from mutant phenotype	17699752	MGI
acts upstream of or within positive regulation of embryonic development	IMP IMP: Inferred from mutant phenotype	12676095	MGI
acts upstream of or within protein localization	IMP IMP: Inferred from mutant phenotype	18824598	MGI
acts upstream of or within regulation of small GTPase mediated signal transduction	IMP IMP: Inferred from mutant phenotype	17699752	MGI
acts upstream of or within vasculogenesis	IMP IMP: Inferred from mutant phenotype	12902404	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in bicellular tight junction	IDA IDA: Inferred from direct assay	17397395	MGI
located in cytoplasmic vesicle	IDA IDA: Inferred from direct assay	17397395	MGI
located in lamellipodium	IDA IDA: Inferred from direct assay	12902404	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

angiomotin

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00663	AMOT Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20691	Amot Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27202	Amot Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Amot	NCBI	NCBI:154796

Name
Email *

	Sorry, but the email address you supplied was invalid.