2. Gene
  3. Pon3 - paraoxonase 3 Gene

Pon3 - paraoxonase 3 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as 2810004E20

Gene ID: 269823 | Gene type: protein coding

About Pon3

Summary

Predicted to enable 3,4-dihydrocoumarin hydrolase activity; arylesterase activity; and protein homodimerization activity. Involved in negative regulation of superoxide anion generation. Predicted to be located in intracellular membrane-bounded organelle. Predicted to be active in extracellular space. Is expressed in several structures, including alimentary system; brain; genitourinary system; hemolymphoid system gland; and liver and biliary system. Human ortholog(s) of this gene implicated in Alzheimer's disease; amyotrophic lateral sclerosis; and atherosclerosis. Orthologous to human PON3 (paraoxonase 3). [provided by Alliance of Genome Resources, Apr 2022]

Pon3 Products(9)

mRNA Protein Name
NM_001363812.2 NP_001350741.1 serum paraoxonase/lactonase 3 isoform 2
NM_001411739.1 NP_001398668.1 serum paraoxonase/lactonase 3 isoform 2
NM_001411740.1 NP_001398669.1 serum paraoxonase/lactonase 3 isoform 2
NM_001411741.1 NP_001398670.1 serum paraoxonase/lactonase 3 isoform 2
NM_001411742.1 NP_001398671.1 serum paraoxonase/lactonase 3 isoform 3 precursor
NM_001411743.1 NP_001398672.1 serum paraoxonase/lactonase 3 isoform 4
NM_001411744.1 NP_001398673.1 serum paraoxonase/lactonase 3 isoform 5
NM_001411745.1 NP_001398674.1 serum paraoxonase/lactonase 3 isoform 5
NM_173006.3 NP_766594.1 serum paraoxonase/lactonase 3 isoform 1 precursor
Gene Ontology
  • Biological Process
Biological Process GO Annotation Evidence Reference Source
acts upstream of establishment of localization in cell IDA
IDA: Inferred from direct assay
32079677 MGI
acts upstream of establishment of localization in cell IMP
IMP: Inferred from mutant phenotype
32079677 MGI
acts upstream of establishment of localization in cell IPI
IPI: Inferred from physical interaction
32079677 MGI
involved in negative regulation of superoxide anion generation IDA
IDA: Inferred from direct assay
22441669 MGI
acts upstream of renal sodium ion transport IDA
IDA: Inferred from direct assay
32079677 MGI
acts upstream of renal sodium ion transport IMP
IMP: Inferred from mutant phenotype
32079677 MGI
acts upstream of renal sodium ion transport IPI
IPI: Inferred from physical interaction
32079677 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

serum paraoxonase/lactonase 3

Related Agents

Pre-clinical Phase
Bioactive Molecules (2)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS10874 PON3 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS21411 Pon3 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Pon3 NCBI NCBI:5446