Chd5 - chromodomain helicase DNA binding protein 5 Gene

Mus musculus

Also known as CHD-5; 4930532L22Rik; B230399N07Rik

Gene ID: 269610 | Gene type: protein coding

About Chd5

Summary

Enables H3K27me3 modified histone binding activity and histone deacetylase binding activity. Involved in several processes, including cerebral cortex neuron differentiation; positive regulation of signal transduction by p53 class mediator; and spermatogenesis, exchange of chromosomal proteins. Located in heterochromatin and nucleus. Part of NuRD complex. Is expressed in central nervous system and dorsal root ganglion. Orthologous to human CHD5 (chromodomain helicase DNA binding protein 5). [provided by Alliance of Genome Resources, Apr 2022]

Chd5 Products(3)

mRNA	Protein	Name
NM_001081376.1	NP_001074845.1	chromodomain-helicase-DNA-binding protein 5 isoform 1
NM_001369243.1	NP_001356172.1	chromodomain-helicase-DNA-binding protein 5 isoform 3
NM_029216.2	NP_083492.2	chromodomain-helicase-DNA-binding protein 5 isoform 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables H3K27me3 modified histone binding	IDA IDA: Inferred from direct assay	23948251	MGI
enables histone binding	IDA IDA: Inferred from direct assay	23318260	MGI
enables histone deacetylase binding	IPI IPI: Inferred from physical interaction	21931736	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	21931736	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in cerebral cortex neuron differentiation	IMP IMP: Inferred from mutant phenotype	23948251	MGI
involved in negative regulation of cell population proliferation	IMP IMP: Inferred from mutant phenotype	17289567	MGI
involved in negative regulation of transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	23318260	MGI
involved in positive regulation of signal transduction by p53 class mediator	IMP IMP: Inferred from mutant phenotype	17289567	MGI
involved in regulation of cell differentiation	IMP IMP: Inferred from mutant phenotype	23318260	MGI
involved in sperm DNA condensation	IMP IMP: Inferred from mutant phenotype	24252660	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
part of NuRD complex	IDA IDA: Inferred from direct assay	21931736	MGI
located in heterochromatin	IDA IDA: Inferred from direct assay	23318260	MGI
located in nucleus	IDA IDA: Inferred from direct assay	23948251	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

chromodomain-helicase-DNA-binding protein 5

ATP-dependent helicase CHD5

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-118780	CHD-5	Antagonist	≥98.0%	Unkown
HY-RS02610	CHD5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18344	Chd5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24823	Chd5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Chd5	NCBI	NCBI:26038

Name
Email *

	Sorry, but the email address you supplied was invalid.