1. Gene
  2. Setx - senataxin Gene

Setx - senataxin Gene

Mus musculus

Also known as AOA2; Als4; Sen1; SCAR1; mKIAA0625; A130090N03; A930037J23Rik

Gene ID: 269254 | Gene type: protein coding

About Setx

Summary

Predicted to enable RNA binding activity; identical protein binding activity; and transcription termination site sequence-specific DNA binding activity. Acts upstream of or within circadian rhythm and termination of RNA polymerase II transcription. Predicted to be located in several cellular components, including growth cone; intercellular bridge; and nuclear lumen. Predicted to be active in nuclear body. Human ortholog(s) of this gene implicated in amyotrophic lateral sclerosis type 4 and ataxia with oculomotor apraxia type 2. Orthologous to human SETX (senataxin). [provided by Alliance of Genome Resources, Apr 2022]

Setx Products(1)

mRNA Protein Name
NM_198033.2 NP_932150.2 probable helicase senataxin
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables protein binding IPI
IPI: Inferred from physical interaction
22767893 MGI
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within circadian rhythm IMP
IMP: Inferred from mutant phenotype
22767893 MGI
acts upstream of or within termination of RNA polymerase II transcription IMP
IMP: Inferred from mutant phenotype
22767893 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

probable helicase senataxin

SEN1 homolog

amyotrophic lateral sclerosis 4 homolog

amyotrophic lateral sclerosis 4 protein homolog

Orthologs Information

Species Symbol Source ID
Homo sapiens Setx NCBI NCBI:23064