2. Gene
  3. Ltbp1 - latent transforming growth factor beta binding protein 1 Gene

Ltbp1 - latent transforming growth factor beta binding protein 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as Tgfb; Ltbp-1; Ltbp1L; 9830146M04; b2b1000Clo; 9430031G15Rik; TGF-beta1-BP-1

Gene ID: 268977 | Gene type: protein coding

About Ltbp1

Summary

Predicted to enable microfibril binding activity and transforming growth factor beta binding activity. Acts upstream of or within aorta development; coronary vasculature development; and ventricular septum development. Located in microfibril. Is expressed in several structures, including embryo mesenchyme; genitourinary system; heart; integumental system; and neural ectoderm. Human ortholog(s) of this gene implicated in cutis laxa. Orthologous to human LTBP1 (latent transforming growth factor beta binding protein 1). [provided by Alliance of Genome Resources, Apr 2022]

Ltbp1 Products(7)

mRNA Protein Name
NM_001331233.1 NP_001318162.1 latent-transforming growth factor beta-binding protein 1 isoform 3 precursor
NM_001331234.1 NP_001318163.1 latent-transforming growth factor beta-binding protein 1 isoform 4 precursor
NM_001331235.1 NP_001318164.1 latent-transforming growth factor beta-binding protein 1 isoform 5 precursor
NM_001331236.1 NP_001318165.1 latent-transforming growth factor beta-binding protein 1 isoform 6 precursor
NM_001331237.1 NP_001318166.1 latent-transforming growth factor beta-binding protein 1 isoform 7 precursor
NM_019919.4 NP_064303.2 latent-transforming growth factor beta-binding protein 1 isoform LTBP-1L precursor
NM_206958.3 NP_996841.1 latent-transforming growth factor beta-binding protein 1 isoform LTBP-1S precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within aorta development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within coronary vasculature development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
acts upstream of or within ventricular septum development IMP
IMP: Inferred from mutant phenotype
25807483 MGI
Cellular Component GO Annotation Evidence Reference Source
located in extracellular matrix IDA
IDA: Inferred from direct assay
9008713 MGI
located in microfibril IDA
IDA: Inferred from direct assay
19349279 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

latent-transforming growth factor beta-binding protein 1

latent TGF beta binding protein

latent transforming growth factor beta binding protein 1L

transforming growth factor beta-1-binding protein 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS07877 LTBP1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20052 Ltbp1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS26556 Ltbp1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ltbp1 NCBI NCBI:4052