Abat - 4-aminobutyrate aminotransferase Gene

Mus musculus

Also known as I54; Gabat; Gabaat; Gm9851; Laibat; 9630038C02Rik

Gene ID: 268860 | Gene type: protein coding

About Abat

Summary

The encoded gene product is responsible for catabolism of gamma-aminobutyric acid (GABA), a mostly inhibitory neurotransmitter in the central nervous system, into succinic semialdehyde. Deficiency of this encoded protein includes psychomotor retardation, hypotonia, hyperreflexia, lethargy, refractory seizures, and EEG abnormalities. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Jan 2010]

Abat Products(2)

mRNA	Protein	Name
NM_001170978.1	NP_001164449.1	4-aminobutyrate aminotransferase, mitochondrial isoform 2 precursor
NM_172961.3	NP_766549.2	4-aminobutyrate aminotransferase, mitochondrial isoform 1 precursor

Gene Ontology

Biological Process

Biological Process GO Annotation	Evidence	Reference	Source
involved in behavioral response to cocaine	IMP IMP: Inferred from mutant phenotype	10850552	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

4-aminobutyrate aminotransferase, mitochondrial

(S)-3-amino-2-methylpropionate transaminase	4-aminobutyrate transaminase
GABA aminotransferase	GABA transaminase
GABA transferase	beta-alanine oxoglutarate aminotransferase
gamma-amino-N-butyrate transaminase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00036	ABAT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18027	Abat Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24500	Abat Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Abat	NCBI	NCBI:18

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