Pclo - piccolo (presynaptic cytomatrix protein) Gene

Mus musculus

Also known as Acz; Pico

Gene ID: 26875 | Gene type: protein coding

About Pclo

Summary

Enables profilin binding activity. A structural constituent of presynaptic active zone. Involved in presynapse to nucleus signaling pathway; protein localization to synapse; and synaptic vesicle clustering. Acts upstream of or within Cytoskeleton organization; Insulin secretion; and regulation of exocytosis. Located in postsynaptic density and presynaptic active zone cytoplasmic component. Is expressed in nervous system and sensory organ. Human ortholog(s) of this gene implicated in pontocerebellar hypoplasia type 3. Orthologous to human PCLO (piccolo presynaptic cytomatrix protein). [provided by Alliance of Genome Resources, Apr 2022]

Pclo Products(2)

mRNA	Protein	Name
NM_001110796.2	NP_001104266.1	protein piccolo isoform 2
NM_011995.4	NP_036125.4	protein piccolo isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables profilin binding	IDA IDA: Inferred from direct assay	10508862	MGI
enables protein binding	IPI IPI: Inferred from physical interaction	12401793	MGI
enables structural constituent of presynaptic active zone	IDA IDA: Inferred from direct assay	26793095	MGI
enables structural constituent of presynaptic active zone	IMP IMP: Inferred from mutant phenotype	26793095	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within cytoskeleton organization	IDA IDA: Inferred from direct assay	10508862	MGI
acts upstream of or within insulin secretion	IDA IDA: Inferred from direct assay	12401793	MGI
involved in presynaptic actin cytoskeleton organization	EXP EXP: Inferred from Experiment	21976510	MGI
involved in presynaptic actin cytoskeleton organization	IDA IDA: Inferred from direct assay	21976510	MGI
involved in presynaptic actin cytoskeleton organization	IMP IMP: Inferred from mutant phenotype	21976510	MGI
involved in protein localization to synapse	IGI IGI: Inferred from genetic interaction	25652077	MGI
acts upstream of or within regulation of exocytosis	IDA IDA: Inferred from direct assay	12401793	MGI
involved in synaptic vesicle clustering	IDA IDA: Inferred from direct assay	20332206	MGI
involved in synaptic vesicle clustering	IMP IMP: Inferred from mutant phenotype	20332206	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in postsynaptic density	IDA IDA: Inferred from direct assay	17114649	MGI
located in synapse	IDA IDA: Inferred from direct assay	10508862	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein piccolo

aczonin	brain-derived HLMN protein
multidomain presynaptic cytomatrix protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10155	PCLO Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS22272	Pclo Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28795	Pclo Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pclo	NCBI	NCBI:27445

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