2. Gene
  3. Txnrd2 - thioredoxin reductase 2 Gene

Txnrd2 - thioredoxin reductase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Mus musculus

Also known as TGR; Tr3; Trxr2; Trxrd2; ESTM573010

Gene ID: 26462 | Gene type: protein coding

About Txnrd2

Summary

The protein encoded by this gene belongs to the pyridine nucleotide-disulfide oxidoreductase family, and is a member of the thioredoxin (Trx) system. Three thioredoxin reductase (TrxR) isozymes are found in mammals. TrxRs are selenocysteine-containing flavoenzymes, which reduce thioredoxins, as well as Other substrates, and play a key role in redox homoeostasis. This gene encodes a mitochondrial form important for scavenging Reactive Oxygen Species in mitochondria. It functions as a homodimer containing FAD, and selenocysteine (Sec) at the active site. Sec is encoded by UGA codon that normally signals translation termination. The 3' UTRs of selenoprotein mRNAs contain a conserved stem-loop structure, the Sec insertion sequence (SECIS) element, which is necessary for the recognition of UGA as a Sec codon rather than as a stop signal. Alternatively spliced transcript variants encoding different isoforms have been described for this gene. [provided by RefSeq, Jun 2017]

Txnrd2 Products(2)

mRNA Protein Name
NM_001353143.1 NP_001340072.1 thioredoxin reductase 2, mitochondrial isoform 2 precursor
NM_013711.3 NP_038739.2 thioredoxin reductase 2, mitochondrial isoform 1 precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
acts upstream of or within heart development IMP
IMP: Inferred from mutant phenotype
15485910 MGI
acts upstream of or within hemopoiesis IMP
IMP: Inferred from mutant phenotype
15485910 MGI
Cellular Component GO Annotation Evidence Reference Source
located in mitochondrion IDA
IDA: Inferred from direct assay
10721726 MGI
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

thioredoxin reductase 2, mitochondrial

TR beta

thioredoxin reductase TR3

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS15299 TXNRD2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS20613 Txnrd2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS27121 Txnrd2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Txnrd2 NCBI NCBI:10587