Creb3l1 - cAMP responsive element binding protein 3-like 1 Gene

Mus musculus

Also known as Oasis

Gene ID: 26427 | Gene type: protein coding

About Creb3l1

Summary

Enables DNA-binding transcription activator activity, RNA polymerase II-specific; cAMP response element binding activity; and chromatin binding activity. Involved in several processes, including extracellular matrix constituent secretion; negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway; and positive regulation of transcription from RNA polymerase II promoter in response to endoplasmic reticulum stress. Acts upstream of or within regulation of ossification. Located in endoplasmic reticulum and nucleus. Is expressed in several structures, including alimentary system; brain; genitourinary system; lung; and skeleton. Human ortholog(s) of this gene implicated in osteogenesis imperfecta type 16. Orthologous to human CREB3L1 (cAMP responsive element binding protein 3 like 1). [provided by Alliance of Genome Resources, Apr 2022]

Creb3l1 Products(1)

mRNA	Protein	Name
NM_011957.2	NP_036087.2	cyclic AMP-responsive element-binding protein 3-like protein 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription activator activity, RNA polymerase II-specific	IDA IDA: Inferred from direct assay	19767743	MGI
enables cAMP response element binding	IDA IDA: Inferred from direct assay	19767743	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	19767743	MGI
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	15665855	MGI

Biological Process GO Annotation	Evidence	Reference	Source
involved in endoplasmic reticulum unfolded protein response	IDA IDA: Inferred from direct assay	19767743	MGI
involved in extracellular matrix constituent secretion	IDA IDA: Inferred from direct assay	19767743	MGI
involved in mitotic G2 DNA damage checkpoint signaling	IDA IDA: Inferred from direct assay	37178686	MGI
involved in negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway	IDA IDA: Inferred from direct assay	15665855	MGI
involved in osteoblast differentiation	IMP IMP: Inferred from mutant phenotype	19767743	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	15665855	MGI
acts upstream of or within regulation of ossification	IMP IMP: Inferred from mutant phenotype	19767743	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	15665855	MGI
is active in nucleus	IDA IDA: Inferred from direct assay	37178686	MGI
located in nucleus	IDA IDA: Inferred from direct assay	15665855	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cyclic AMP-responsive element-binding protein 3-like protein 1

BBF-2 homolog	cAMP-responsive element-binding protein 3-like protein 1
old astrocyte specifically induced substance

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS03150	CREB3L1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17784	Creb3l1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24251	Creb3l1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Creb3l1	NCBI	NCBI:90993

Name
Email *

	Sorry, but the email address you supplied was invalid.