Fkbp4 - FKBP prolyl isomerase 4 Gene

Rattus norvegicus

Also known as p59; FKBP-4; FKBP-52

Gene ID: 260321 | Gene type: protein coding

About Fkbp4

Summary

Enables copper-dependent protein binding activity and Tau Protein binding activity. Involved in copper ion transport and negative regulation of microtubule polymerization. Located in several cellular components, including axonal growth cone; neuronal cell body; and perinuclear region of cytoplasm. Part of protein-containing complex. Orthologous to human FKBP4 (FKBP prolyl isomerase 4). [provided by Alliance of Genome Resources, Apr 2022]

Fkbp4 Products(1)

mRNA	Protein	Name
NM_001191863.1	NP_001178792.1	peptidyl-prolyl cis-trans isomerase FKBP4

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables copper-dependent protein binding	IPI IPI: Inferred from physical interaction	15133031	RGD
enables tau protein binding	IPI IPI: Inferred from physical interaction	20133804	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in copper ion transport	IMP IMP: Inferred from mutant phenotype	15133031	RGD
involved in negative regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	17435176	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axonal growth cone	IDA IDA: Inferred from direct assay	20133804	RGD
located in cytosol	IDA IDA: Inferred from direct assay	20133804	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	20796173	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20796173	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	20796173	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

peptidyl-prolyl cis-trans isomerase FKBP4

52 kDa FK506-binding protein	52 kDa FKBP
59 kDa immunophilin	FK506 binding protein 52
FK506-binding protein 4	FKBP52 protein
FKBP59	HBI
HSP-binding immunophilin	PPIase FKBP4
immunophilin FKBP52	rotamase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS04964	FKBP4 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18819	Fkbp4 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25309	Fkbp4 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fkbp4	NCBI	NCBI:2288

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