REXO2 - RNA exonuclease 2 Gene

Homo sapiens

Also known as RFN; SFN; REX2; CGI-114

Gene ID: 25996 | Gene type: protein coding

About REXO2

Cytogenetic location: 11q23.2 Genomic coordinates (GRCh38): 11:114,439,467-114,450,279 (from NCBI)

This gene has 19 transcripts (splice variants) and 214 orthologues. Ubiquitous expression in heart (RPKM 41.6), kidney (RPKM 38.9) and 25 other tissues.

Summary

This gene encodes a 3'-to-5' exonuclease specific for small (primarily 5 nucleotides or less in length) single-stranded RNA and DNA oligomers. This protein may have a role in DNA repair, replication, and recombination, and in RNA processing and degradation. It may also be involved in resistance of human cells to UV-C-induced cell death through its role in the DNA repair process. [provided by RefSeq, Nov 2011]

REXO2 Products(1)

mRNA	Protein	Name
NM_015523.4	NP_056338.2	oligoribonuclease, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables 3'-5' exonuclease activity	IDA IDA: Inferred from direct assay	10851236	GOA
enables 3'-5' exonuclease activity	IMP IMP: Inferred from mutant phenotype	23741365	GOA
enables 3'-5'-DNA exonuclease activity	IDA IDA: Inferred from direct assay	31588022	GOA
enables 3'-5'-RNA exonuclease activity	IDA IDA: Inferred from direct assay	31588022	GOA
enables 3'-5'-RNA exonuclease activity	IMP IMP: Inferred from mutant phenotype	30926754	GOA
enables magnesium ion binding	IDA IDA: Inferred from direct assay	30926754	GOA

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within nucleobase-containing compound metabolic process	IDA IDA: Inferred from direct assay	10851236	GOA

Cellular Component GO Annotation	Evidence	Reference	Source
located in cytoplasm	IDA IDA: Inferred from direct assay	32365187	GOA
located in mitochondrial intermembrane space	IDA IDA: Inferred from direct assay	23741365	GOA
located in mitochondrial matrix	IDA IDA: Inferred from direct assay	23741365	GOA
located in mitochondrion	IDA IDA: Inferred from direct assay	32365187	GOA
located in nucleus	IDA IDA: Inferred from direct assay	32365187	GOA

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

REXO2 Protein Structure

RNase_T

0
100
200
237 a.a.

Protein Preferred Names

Protein Names

oligoribonuclease, mitochondrial

REX2, RNA exonuclease 2 homolog

Related Diseases

Diseases

Alias

Gallbladder Melanoma

Malignant Melanoma Of Gallbladder

Noonan Syndrome 1

Noonan Syndrome	NS1
Male Turner Syndrome	Female Pseudo-Turner Syndrome
Turner Phenotype With Normal Karyotype	Noonan Syndrome With Pigmented Villonodular Synovitis
Turner'S Phenotype, Karyotype Normal	Familial Turner Syndrome
Noonan'S Syndrome	Noonan-Ehmke Syndrome
Ns	Pseudo-Ullrich-Turner Syndrome
Turner Syndrome In Female With X Chromosome	Turner-Like Syndrome
Ullrich-Noonan Syndrome	Noonan-Like/Multiple Giant Cell Lesion Syndrome
Noonan Syndrome-Like Disorder With Multiple Giant Cell Lesions	Pterygium Colli Syndrome
Noonan Syndrome, Type 1	Turner Syndrome, Male

Diseases	Alias
Waldenstroem'S Macroglobulinemia	Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma Waldenstroem'S Macroglobulinemia Waldenstroem'S Macroglobulinemia Macroglobulinemia Of Waldenstrom Lymphoplasmacytic Lymphoma With Igm Gammopathy Lymphoplasmacytic Lymphoma

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS11864	REXO2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20094	Rexo2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26597	Rexo2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Felis catus	REXO2	VGNC	VGNC:64581
Macaca mulatta	REXO2	VGNC	VGNC:76757
Mus musculus	REXO2	MGD	MGI:1888981
Rattus norvegicus	REXO2	RGD	RGD:1304874
Canis familiaris	REXO2	VGNC	VGNC:45490
Bos taurus	REXO2	VGNC	VGNC:33884

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