Cpt1a - carnitine palmitoyltransferase 1A Gene

Rattus norvegicus

Also known as CPT-Ia

Gene ID: 25757 | Gene type: protein coding

About Cpt1a

Summary

Enables carnitine O-palmitoyltransferase activity and identical protein binding activity. Involved in several processes, including fatty acid metabolic process; liver regeneration; and response to tetrachloromethane. Located in mitochondrial outer membrane. Is integral component of mitochondrial outer membrane. Biomarker of alcoholic hepatitis; obesity; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in carnitine palmitoyltransferase I deficiency and lipid metabolism disorder. Orthologous to human CPT1A (carnitine palmitoyltransferase 1A). [provided by Alliance of Genome Resources, Apr 2022]

Cpt1a Products(1)

mRNA	Protein	Name
NM_031559.2	NP_113747.2	carnitine O-palmitoyltransferase 1, liver isoform

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables carnitine O-palmitoyltransferase activity	IDA IDA: Inferred from direct assay	11790778	RGD
enables carnitine O-palmitoyltransferase activity	IMP IMP: Inferred from mutant phenotype	9169604	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	19136561	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	19429947	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in aflatoxin metabolic process	IEP IEP: Inferred from expression pattern	28959666	RGD
involved in carnitine metabolic process	IDA IDA: Inferred from direct assay	21990363	RGD
involved in cellular response to fatty acid	IEP IEP: Inferred from expression pattern	19332540	RGD
involved in eating behavior	IMP IMP: Inferred from mutant phenotype	12754501	RGD
involved in fatty acid beta-oxidation	IEP IEP: Inferred from expression pattern	31901136	RGD
involved in fatty acid metabolic process	IDA IDA: Inferred from direct assay	24222496	RGD
involved in fatty acid metabolic process	IEP IEP: Inferred from expression pattern	30851372	RGD
involved in glucose metabolic process	IMP IMP: Inferred from mutant phenotype	12754501	RGD
involved in liver regeneration	IEP IEP: Inferred from expression pattern	31953200	RGD
involved in long-chain fatty acid metabolic process	IDA IDA: Inferred from direct assay	21990363	RGD
involved in long-chain fatty acid metabolic process	IMP IMP: Inferred from mutant phenotype	19302064	RGD
involved in positive regulation of fatty acid beta-oxidation	IMP IMP: Inferred from mutant phenotype	19302064	RGD
involved in regulation of fatty acid oxidation	IMP IMP: Inferred from mutant phenotype	11988095	RGD
involved in regulation of insulin secretion	IMP IMP: Inferred from mutant phenotype	11988095	RGD
involved in regulation of lipid storage	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to alkaloid	IEP IEP: Inferred from expression pattern	30868489	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	33310031	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	33310031	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	30851372	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16751799	RGD
involved in response to tetrachloromethane	IEP IEP: Inferred from expression pattern	31918260	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19553925	RGD
involved in triglyceride metabolic process	IMP IMP: Inferred from mutant phenotype	18349115	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
NOT located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	12401113	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	9169604	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

carnitine O-palmitoyltransferase 1, liver isoform

CPT I	CPT1-L
CPTI-L	carnitine palmitoyltransferase 1, liver
carnitine palmitoyltransferase 1a, liver

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-115938	BEC2	Inhibitor	≥98.0%	Phase 3

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-50202	Etomoxir	Inducer	99.92%	Yes
HY-12364	C75	Inhibitor	99.91%	Unkown
HY-50202A	Etomoxir sodium salt	Inducer	99.62%	Yes
HY-W588256	12-Tridecenoic acid	Activator	/	Unkown
HY-W420033	(S)-(+)-Etomoxir	Control	98.65%	Unkown
HY-N8144	Niga-ichigoside F1		≥99.0%	Unkown
HY-RS03122	CPT1A Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16248	Cpt1a Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-116257	GSK-7227	Agonist	/	Unkown
HY-12364B	(−)-C75	Inhibitor	/	Unkown
HY-161027	DHP-B	Inducer	/	Unkown
HY-N9333	Wistin	Agonist	/	Unkown
HY-RS23138	Cpt1a Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cpt1a	NCBI	NCBI:1374

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