2. Gene
  3. Itgb4 - integrin subunit beta 4 Gene

Itgb4 - integrin subunit beta 4 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus
Gene ID: 25724 | Gene type: protein coding

About Itgb4

Summary

Predicted to enable G protein-coupled receptor binding activity and Integrin binding activity. Predicted to contribute to insulin-like growth factor I binding activity and neuregulin binding activity. Predicted to be involved in several processes, including hemidesmosome assembly; integrin-mediated signaling pathway; and skin morphogenesis. Predicted to act upstream of or within several processes, including filopodium assembly; peripheral nervous system myelin formation; and trophoblast cell migration. Located in cell cortex and membrane. Human ortholog(s) of this gene implicated in junctional epidermolysis bullosa non-Herlitz type and junctional epidermolysis bullosa with pyloric atresia. Orthologous to human ITGB4 (Integrin subunit beta 4). [provided by Alliance of Genome Resources, Apr 2022]

Itgb4 Products(1)

mRNA Protein Name
NM_013180.2 NP_037312.2 integrin beta-4 precursor
Gene Ontology
  • Cellular Component
Cellular Component GO Annotation Evidence Reference Source
located in cell cortex IDA
IDA: Inferred from direct assay
16409251 RGD
is active in glutamatergic synapse IDA
IDA: Inferred from direct assay
27518800 RGD
is active in postsynaptic membrane IDA
IDA: Inferred from direct assay
27518800 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

integrin beta-4

GP150

Related Agents

Clinical Phase
Bioactive Molecules (1)
Cat. No. Product Name Effect
Purity Phase
HY-125355 SEC Inducer 98.26% Phase 1
Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS06968 ITGB4 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS17507 Itgb4 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23964 Itgb4 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Itgb4 NCBI NCBI:3691