Hcrt - hypocretin neuropeptide precursor Gene

Rattus norvegicus

Also known as orexin-A

Gene ID: 25723 | Gene type: protein coding

About Hcrt

Summary

Enables neuropeptide hormone activity; type 1 hypocretin receptor binding activity; and type 2 hypocretin receptor binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; regulation of metal ion transport; and regulation of transmission of nerve impulse. Located in secretory granule. Biomarker of hyperglycemia and obesity. Human ortholog(s) of this gene implicated in narcolepsy. Orthologous to human HCRT (hypocretin neuropeptide precursor). [provided by Alliance of Genome Resources, Apr 2022]

Hcrt Products(1)

mRNA	Protein	Name
NM_013179.3	NP_037311.1	hypocretin neuropeptide precursor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables neuropeptide hormone activity	IDA IDA: Inferred from direct assay	16247802	RGD
enables type 1 orexin receptor binding	IDA IDA: Inferred from direct assay	12890892	RGD
enables type 2 orexin receptor binding	IDA IDA: Inferred from direct assay	12890892	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in eating behavior	IDA IDA: Inferred from direct assay	15961555	RGD
involved in excitatory postsynaptic potential	IDA IDA: Inferred from direct assay	16247802	RGD
involved in negative regulation of DNA replication	IDA IDA: Inferred from direct assay	16141395	RGD
involved in negative regulation of potassium ion transport	IDA IDA: Inferred from direct assay	16247802	RGD
involved in negative regulation of transmission of nerve impulse	IDA IDA: Inferred from direct assay	15746258	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	16247802	RGD
involved in positive regulation of calcium ion transport	IMP IMP: Inferred from mutant phenotype	15858425	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	15858425	RGD
involved in positive regulation of transmission of nerve impulse	IDA IDA: Inferred from direct assay	15746258	RGD
involved in regulation of neurotransmitter secretion	IDA IDA: Inferred from direct assay	15664710	RGD
NOT involved in release of sequestered calcium ion into cytosol	IMP IMP: Inferred from mutant phenotype	15858425	RGD
involved in response to alcohol	IEP IEP: Inferred from expression pattern	32619610	RGD
involved in temperature homeostasis	IDA IDA: Inferred from direct assay	15479129	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
is active in neuronal dense core vesicle lumen	IDA IDA: Inferred from direct assay	9419374	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	9419374	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hypocretin neuropeptide precursor

Hypocretin (orexin) neuropeptide	orexin
prepro-orexin	preprohypocretin

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-128850	N-Acetyl-D-mannosamine		99.58%	Phase 2

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06050	HCRT Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18943	Hcrt Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25433	Hcrt Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hcrt	NCBI	NCBI:3060

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