Tgfb3 - transforming growth factor, beta 3 Gene

Rattus norvegicus

Also known as TGF-B3

Gene ID: 25717 | Gene type: protein coding

About Tgfb3

Summary

Predicted to enable several functions, including cytokine activity; transforming growth factor beta binding activity; and transforming growth factor beta receptor binding activity. Involved in several processes, including regulation of signal transduction; response to estrogen; and skeletal system morphogenesis. Located in several cellular components, including T-tubule; neuronal cell body; and secretory granule. Biomarker of diabetic neuropathy. Human ortholog(s) of this gene implicated in Loeys-Dietz syndrome 5; arrhythmogenic right ventricular cardiomyopathy; and arrhythmogenic right ventricular dysplasia 1. Orthologous to human TGFB3 (transforming growth factor beta 3). [provided by Alliance of Genome Resources, Apr 2022]

Tgfb3 Products(1)

mRNA	Protein	Name
NM_013174.2	NP_037306.1	transforming growth factor beta-3 proprotein preproprotein

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	18406405	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in digestive tract development	IEP IEP: Inferred from expression pattern	12815632	RGD
involved in embryonic neurocranium morphogenesis	IDA IDA: Inferred from direct assay	11002343	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	15927076	RGD
involved in frontal suture morphogenesis	IEP IEP: Inferred from expression pattern	12416537	RGD
involved in inner ear development	IEP IEP: Inferred from expression pattern	16479080	RGD
involved in negative regulation of cell population proliferation	IDA IDA: Inferred from direct assay	11002343	RGD
involved in negative regulation of transforming growth factor beta receptor signaling pathway	IDA IDA: Inferred from direct assay	12071374	RGD
involved in positive regulation of MAPK cascade	IDA IDA: Inferred from direct assay	14605008	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	11002343	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16532270	RGD
involved in response to estrogen	IDA IDA: Inferred from direct assay	14605008	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	14697406	RGD
involved in response to laminar fluid shear stress	IEP IEP: Inferred from expression pattern	16217485	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in T-tubule	IDA IDA: Inferred from direct assay	9281452	RGD
located in cell surface	IDA IDA: Inferred from direct assay	16479080	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	16891311	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	15214860	RGD
located in secretory granule	IDA IDA: Inferred from direct assay	15214860	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

transforming growth factor beta-3 proprotein

TGF-beta-3

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS14442	TGFB3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16996	Tgfb3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23439	Tgfb3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Tgfb3	NCBI	NCBI:7043
Mus musculus	Tgfb3	NCBI	NCBI:21809

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