Slc11a2 - solute carrier family 11 member 2 Gene

Rattus norvegicus

Also known as Dmt1; Nramp2

Gene ID: 25715 | Gene type: protein coding

About Slc11a2

Summary

Enables lead ion transmembrane transporter activity; transition metal ion binding activity; and transition metal ion transmembrane transporter activity. Involved in several processes, including cellular response to tumor necrosis factor; response to lead ion; and transition metal ion transport. Located in apical part of cell; late endosome membrane; and lysosomal membrane. Is integral component of membrane. Used to study Parkinsonism; hypochromic anemia; and pneumonia. Biomarker of brain ischemia; duodenal ulcer; and iron deficiency anemia. Human ortholog(s) of this gene implicated in Parkinson's disease; amyotrophic lateral sclerosis; anemia; and hypochromic anemia. Orthologous to human SLC11A2 (solute carrier family 11 member 2). [provided by Alliance of Genome Resources, Apr 2022]

Slc11a2 Products(2)

mRNA	Protein	Name
NM_001399169.1	NP_001386098.1	natural resistance-associated macrophage protein 2 isoform 2
NM_013173.2	NP_037305.2	natural resistance-associated macrophage protein 2 isoform 1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cadmium ion binding	IDA IDA: Inferred from direct assay	9242408	RGD
enables cadmium ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9242408	RGD
enables cobalt ion binding	IDA IDA: Inferred from direct assay	9242408	RGD
enables cobalt ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9242408	RGD
enables copper ion binding	IDA IDA: Inferred from direct assay	9242408	RGD
enables copper ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9242408	RGD
enables ferrous iron transmembrane transporter activity	IMP IMP: Inferred from mutant phenotype	16091957	RGD
enables iron ion binding	IDA IDA: Inferred from direct assay	9242408	RGD
enables iron ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9242408	RGD
enables lead ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9242408	RGD
enables manganese ion binding	IDA IDA: Inferred from direct assay	9242408	RGD
enables manganese ion transmembrane transporter activity	IDA IDA: Inferred from direct assay	9242408	RGD
enables nickel cation binding	IDA IDA: Inferred from direct assay	9242408	RGD
enables nickel cation transmembrane transporter activity	IDA IDA: Inferred from direct assay	9242408	RGD
enables zinc ion binding	IDA IDA: Inferred from direct assay	9242408	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	21325818	RGD
involved in cellular response to iron ion	IEP IEP: Inferred from expression pattern	17663481	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	16221503	RGD
involved in copper ion import across plasma membrane	IMP IMP: Inferred from mutant phenotype	22442359	RGD
involved in iron ion transport	IMP IMP: Inferred from mutant phenotype	16091957	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	19083094	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	21325818	RGD
involved in response to iron ion	IEP IEP: Inferred from expression pattern	12876064	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	19083094	RGD
involved in response to manganese ion	IEP IEP: Inferred from expression pattern	17060373	RGD
involved in response to manganese ion	IMP IMP: Inferred from mutant phenotype	18849539	RGD
involved in transition metal ion transport	IDA IDA: Inferred from direct assay	9242408	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	18420243	RGD
located in late endosome membrane	IDA IDA: Inferred from direct assay	16449358	RGD
located in lysosomal membrane	IDA IDA: Inferred from direct assay	16449358	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

natural resistance-associated macrophage protein 2

DMT-1	NRAMP 2
Solute carrier family 11 member 2 (natural resistance-associated macrophage protein 2)	divalent cation transporter 1
divalent metal transporter 1	solute carrier family 11 (proton-coupled divalent metal ion transporter), member 2
solute

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12995	SLC11A2 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20644	Slc11a2 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS27154	Slc11a2 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Slc11a2	NCBI	NCBI:4891

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