Hmbs - hydroxymethylbilane synthase Gene

Rattus norvegicus

Also known as PBGD; hemC; PBG-D; URO-S

Gene ID: 25709 | Gene type: protein coding

About Hmbs

Summary

Enables several functions, including amine binding activity; hydroxymethylbilane synthase activity; and uroporphyrinogen-III synthase activity. Involved in several processes, including cellular response to dexamethasone stimulus; cellular response to lead ion; and response to estradiol. Located in several cellular components, including axon; cytosol; and perinuclear region of cytoplasm. Colocalizes with condensed chromosome. Biomarker of bilirubin metabolic disorder and liver carcinoma. Human ortholog(s) of this gene implicated in acute intermittent porphyria and sickle cell anemia. Orthologous to human HMBS (hydroxymethylbilane synthase). [provided by Alliance of Genome Resources, Apr 2022]

Hmbs Products(1)

mRNA	Protein	Name
NM_013168.2	NP_037300.2	porphobilinogen deaminase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables amine binding	IPI IPI: Inferred from physical interaction	9344466	RGD
enables carboxylic acid binding	IPI IPI: Inferred from physical interaction	9344466	RGD
enables hydroxymethylbilane synthase activity	IDA IDA: Inferred from direct assay	593266	RGD
enables hydroxymethylbilane synthase activity	IMP IMP: Inferred from mutant phenotype	18760440	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	12917623	RGD
enables uroporphyrinogen-III synthase activity	IDA IDA: Inferred from direct assay	6466301	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in animal organ regeneration	IEP IEP: Inferred from expression pattern	2886336	RGD
involved in astrocyte differentiation	IEP IEP: Inferred from expression pattern	12917623	RGD
involved in cellular response to amine stimulus	IEP IEP: Inferred from expression pattern	10416273	RGD
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	19688726	RGD
involved in cellular response to arsenic-containing substance	IEP IEP: Inferred from expression pattern	10416273	RGD
involved in cellular response to cytokine stimulus	IEP IEP: Inferred from expression pattern	4019471	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	7917467	RGD
involved in cellular response to lead ion	IEP IEP: Inferred from expression pattern	16566714	RGD
involved in liver development	IDA IDA: Inferred from direct assay	971328	RGD
involved in porphyrin-containing compound biosynthetic process	IDA IDA: Inferred from direct assay	971328	RGD
involved in porphyrin-containing compound metabolic process	IDA IDA: Inferred from direct assay	593266	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	8295845	RGD
involved in response to carbohydrate	IEP IEP: Inferred from expression pattern	17285311	RGD
involved in response to cobalt ion	IEP IEP: Inferred from expression pattern	6688350	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	10416826	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	9468112	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	3697363	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	16566714	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	4040350	RGD
involved in response to methylmercury	IEP IEP: Inferred from expression pattern	3327437	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	8000239	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	3580703	RGD
involved in response to vitamin	IEP IEP: Inferred from expression pattern	9559098	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	6893114	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	10571258	RGD
involved in response to zinc ion	IEP IEP: Inferred from expression pattern	8582750	RGD
involved in tetrapyrrole biosynthetic process	IDA IDA: Inferred from direct assay	6712591	RGD
involved in tetrapyrrole biosynthetic process	IMP IMP: Inferred from mutant phenotype	18760440	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in axon	IDA IDA: Inferred from direct assay	11202056	RGD
located in condensed chromosome	IDA IDA: Inferred from direct assay	12917623	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	11202056	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

porphobilinogen deaminase

alternative name: porphobilinogen deaminase	pre-uroporphyrinogen synthase
uroporphyrinogen I synthase

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-119524	Clofibride		/	Unkown
HY-137281	HMB-Val-Ser-Leu-VE	Inhibitor	/	Unkown
HY-RS06224	HMBS Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18945	Hmbs Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25435	Hmbs Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Hmbs	NCBI	NCBI:3145

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