Ass1 - argininosuccinate synthase 1 Gene

Rattus norvegicus

Also known as Ass; ASSA

Gene ID: 25698 | Gene type: protein coding

About Ass1

Summary

Enables argininosuccinate synthase activity and toxic substance binding activity. Involved in several processes, including cellular response to cytokine stimulus; cellular response to lipid; and cellular response to organonitrogen compound. Located in several cellular components, including cell body fiber; mitochondrial outer membrane; and perikaryon. Biomarker of uveitis. Human ortholog(s) of this gene implicated in citrullinemia; classic citrullinemia; hepatocellular carcinoma; and melanoma. Orthologous to human ASS1 (argininosuccinate synthase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ass1 Products(1)

mRNA	Protein	Name
NM_013157.4	NP_037289.1	argininosuccinate synthase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables argininosuccinate synthase activity	IDA IDA: Inferred from direct assay	4062872	RGD
enables argininosuccinate synthase activity	IMP IMP: Inferred from mutant phenotype	19491403	RGD
enables toxic substance binding	IPI IPI: Inferred from physical interaction	11083085	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in L-arginine biosynthetic process	IDA IDA: Inferred from direct assay	12470967	RGD
involved in L-arginine biosynthetic process	IMP IMP: Inferred from mutant phenotype	19491403	RGD
involved in acute-phase response	IEP IEP: Inferred from expression pattern	15698416	RGD
involved in argininosuccinate metabolic process	IDA IDA: Inferred from direct assay	4062872	RGD
involved in cellular response to amine stimulus	IEP IEP: Inferred from expression pattern	18457831	RGD
involved in cellular response to amino acid stimulus	IEP IEP: Inferred from expression pattern	9893939	RGD
involved in cellular response to ammonium ion	IEP IEP: Inferred from expression pattern	10353334	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	8923475	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	9395312	RGD
involved in cellular response to glucagon stimulus	IEP IEP: Inferred from expression pattern	9395312	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	9879717	RGD
involved in cellular response to oleic acid	IEP IEP: Inferred from expression pattern	8985169	RGD
involved in cellular response to tumor necrosis factor	IEP IEP: Inferred from expression pattern	11072090	RGD
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	11072090	RGD
involved in diaphragm development	IEP IEP: Inferred from expression pattern	9618389	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	10473900	RGD
involved in liver development	IEP IEP: Inferred from expression pattern	9395312	RGD
involved in midgut development	IEP IEP: Inferred from expression pattern	9544996	RGD
involved in response to amine	IEP IEP: Inferred from expression pattern	16168957	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	17938381	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	16339744	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	19651254	RGD
involved in response to glucocorticoid	IDA IDA: Inferred from direct assay	8923475	RGD
involved in response to growth hormone	IEP IEP: Inferred from expression pattern	9688877	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	12589771	RGD
involved in response to mycotoxin	IDA IDA: Inferred from direct assay	11083085	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	15257170	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	9688877	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	9688877	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	20452409	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	9252090	RGD
involved in response to zinc ion	IDA IDA: Inferred from direct assay	11686784	RGD
involved in urea cycle	IDA IDA: Inferred from direct assay	4062872	RGD
involved in urea cycle	IMP IMP: Inferred from mutant phenotype	19491403	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in cell body fiber	IDA IDA: Inferred from direct assay	12445581	RGD
located in mitochondrial outer membrane	IDA IDA: Inferred from direct assay	8867809	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	12445581	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	17900569	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

argininosuccinate synthase

argininosuccinate synthetase 1	arginosuccinate synthetase 1
citrulline--aspartate ligase

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-156112	LM2I	Activator	99.78%	Unkown
HY-RS01109	ASS1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17217	Ass1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23669	Ass1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Ass1	NCBI	NCBI:445

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