Has2 - hyaluronan synthase 2 Gene

Rattus norvegicus

Gene ID: 25694 | Gene type: protein coding

About Has2

Summary

Enables hyaluronan synthase activity. Involved in several processes, including estrous cycle; hyaluronan biosynthetic process; and positive regulation of cell migration. Predicted to be located in cytoplasmic vesicle and plasma membrane raft. Predicted to be integral component of plasma membrane. Biomarker of diabetes insipidus; middle cerebral artery infarction; and pulmonary hypertension. Orthologous to human HAS2 (hyaluronan synthase 2). [provided by Alliance of Genome Resources, Apr 2022]

Has2 Products(1)

mRNA	Protein	Name
NM_013153.2	NP_037285.1	hyaluronan synthase 2

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables hyaluronan synthase activity	IDA IDA: Inferred from direct assay	19635555	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in estrous cycle	IEP IEP: Inferred from expression pattern	24218629	RGD
involved in hyaluronan biosynthetic process	IEP IEP: Inferred from expression pattern	19635555	RGD
involved in kidney development	IEP IEP: Inferred from expression pattern	17706761	RGD
involved in positive regulation of hyaluronan biosynthetic process	IDA IDA: Inferred from direct assay	12186949	RGD
involved in positive regulation of hyaluronan biosynthetic process	IMP IMP: Inferred from mutant phenotype	17080198	RGD
involved in positive regulation of keratinocyte migration	IDA IDA: Inferred from direct assay	12186949	RGD
involved in positive regulation of keratinocyte proliferation	IMP IMP: Inferred from mutant phenotype	12186949	RGD
involved in positive regulation of smooth muscle cell migration	IMP IMP: Inferred from mutant phenotype	17080198	RGD
involved in positive regulation of substrate adhesion-dependent cell spreading	IMP IMP: Inferred from mutant phenotype	12186949	RGD
involved in positive regulation of urine volume	IEP IEP: Inferred from expression pattern	19635555	RGD
involved in regulation of extracellular matrix assembly	IMP IMP: Inferred from mutant phenotype	27094859	RGD
involved in renal water absorption	IEP IEP: Inferred from expression pattern	19635555	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

hyaluronan synthase 2

HA synthase 2	hyaluronate synthase 2
hyaluronic acid synthase 2

Related Agents

Approval

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-14803	Tasimelteon	Agonist	99.68%	Yes

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-116973	L 738372	Inhibitor	/	Unkown
HY-RS06007	HAS2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-14803S	Tasimelteon-d5	Agonist	/	Unkown
HY-RS17492	Has2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23949	Has2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Has2	NCBI	NCBI:3037
Mus musculus	Has2	NCBI	NCBI:15117

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