Itpr3 - inositol 1,4,5-trisphosphate receptor, type 3 Gene

Rattus norvegicus

Also known as IP3R3; IP3R-3; IP3R3X

Gene ID: 25679 | Gene type: protein coding

About Itpr3

Summary

Enables several functions, including alcohol binding activity; identical protein binding activity; and inositol 1,4,5-trisphosphate-sensitive calcium-release channel activity. Involved in G protein-coupled receptor signaling pathway; cellular response to cAMP; and positive regulation of cytosolic calcium ion concentration. Located in several cellular components, including brush border; neuronal cell body; and nuclear outer membrane. Is active in presynapse. Is integral component of endoplasmic reticulum membrane. Human ortholog(s) of this gene implicated in type 1 diabetes mellitus. Orthologous to human ITPR3 (inositol 1,4,5-trisphosphate receptor type 3). [provided by Alliance of Genome Resources, Apr 2022]

Itpr3 Products(1)

mRNA	Protein	Name
NM_013138.2	NP_037270.2	inositol 1,4,5-trisphosphate receptor type 3

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables calcium ion binding	IDA IDA: Inferred from direct assay	17320950	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	10694253	RGD
enables inositol 1,3,4,5 tetrakisphosphate binding	IDA IDA: Inferred from direct assay	8388391	RGD
enables inositol 1,4,5 trisphosphate binding	IDA IDA: Inferred from direct assay	17320950	RGD
enables inositol 1,4,5-trisphosphate-gated calcium channel activity	IDA IDA: Inferred from direct assay	10694253	RGD
enables inositol hexakisphosphate binding	IDA IDA: Inferred from direct assay	8388391	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	21424589	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	10694253	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	11788349	RGD
involved in cellular response to cAMP	IDA IDA: Inferred from direct assay	20189985	RGD
involved in positive regulation of cytosolic calcium ion concentration	IDA IDA: Inferred from direct assay	11788349	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical part of cell	IDA IDA: Inferred from direct assay	8288584	RGD
located in apical plasma membrane	IDA IDA: Inferred from direct assay	18005397	RGD
located in brush border	IDA IDA: Inferred from direct assay	8288584	RGD
located in dendrite	IDA IDA: Inferred from direct assay	17471556	RGD
located in endoplasmic reticulum	IDA IDA: Inferred from direct assay	19116207	RGD
is active in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	10096607	RGD
located in endoplasmic reticulum membrane	IDA IDA: Inferred from direct assay	15533917	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	17091480	RGD
located in nuclear envelope	IDA IDA: Inferred from direct assay	15537642	RGD
located in nuclear outer membrane	IDA IDA: Inferred from direct assay	8388391	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	21550988	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	10096607	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

inositol 1,4,5-trisphosphate receptor type 3

IP3 receptor	IP3R 3
inositol 1,4,5-triphosphate receptor 3	inositol 1,4,5-triphosphate receptor, type 3
insP3R3	type 3 InsP3 receptor
type 3 inositol 1,4,5-trisphosphate receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06993	ITPR3 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS21604	Itpr3 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS28122	Itpr3 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Itpr3	NCBI	NCBI:3710

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