Anxa5 - annexin A5 Gene

Rattus norvegicus

Also known as LC5; Anx5; CPB-I

Gene ID: 25673 | Gene type: protein coding

About Anxa5

Summary

Enables several functions, including P-type calcium transporter activity; calcium-dependent phospholipid binding activity; and receptor tyrosine kinase binding activity. Involved in several processes, including cellular response to gonadotropin-releasing hormone; cellular response to lead ion; and negative regulation of Prolactin secretion. Located in several cellular components, including Z disc; intercalated disc; and perikaryon. Biomarker of several diseases, including Wilson disease; cryptorchidism; glomerulonephritis; hyperthyroidism; and myocardial infarction. Human ortholog(s) of this gene implicated in autoimmune disease of the nervous system; myocardial infarction; and systemic scleroderma. Orthologous to human ANXA5 (annexin A5). [provided by Alliance of Genome Resources, Apr 2022]

Anxa5 Products(1)

mRNA	Protein	Name
NM_013132.2	NP_037264.2	annexin A5

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables P-type calcium transporter activity	IDA IDA: Inferred from direct assay	9299392	RGD
enables calcium-dependent phospholipid binding	IDA IDA: Inferred from direct assay	2307675	RGD
enables calcium-dependent phospholipid binding	IMP IMP: Inferred from mutant phenotype	12401794	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	12401794	RGD
enables peptide hormone binding	IDA IDA: Inferred from direct assay	1386737	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	8667030	RGD
enables receptor tyrosine kinase binding	IPI IPI: Inferred from physical interaction	10329451	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to gonadotropin-releasing hormone	IMP IMP: Inferred from mutant phenotype	18504344	RGD
involved in cellular response to lead ion	IEP IEP: Inferred from expression pattern	11578147	RGD
involved in negative regulation of blood coagulation	IDA IDA: Inferred from direct assay	20684318	RGD
involved in negative regulation of prolactin secretion	IMP IMP: Inferred from mutant phenotype	15256781	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	15537503	RGD
involved in regulation of flagellated sperm motility	IDA IDA: Inferred from direct assay	20684318	RGD
involved in response to calcium ion	IDA IDA: Inferred from direct assay	8362244	RGD
involved in response to thyroid hormone	IEP IEP: Inferred from expression pattern	9022675	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	7585827	RGD
located in axon terminus	IDA IDA: Inferred from direct assay	8931014	RGD
located in cell projection	IDA IDA: Inferred from direct assay	1833446	RGD
located in dendrite	IDA IDA: Inferred from direct assay	8931014	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	11271515	RGD
located in intercalated disc	IDA IDA: Inferred from direct assay	1833446	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	8725344	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	8931014	RGD
located in sarcolemma	IDA IDA: Inferred from direct assay	1833446	RGD
located in synaptic vesicle	IDA IDA: Inferred from direct assay	8931014	RGD
is active in synaptic vesicle membrane	IDA IDA: Inferred from direct assay	8931014	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

annexin A5

Annexin V	CBP-I
PAP-I	PP4
VAC-alpha	anchorin CII
annexin-5	calphobindin I
endonexin II	lipocortin V
placental anticoagulant protein 4	placental anticoagulant protein I
thromboplastin inhibitor	vascular anticoagulant-alpha

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00765	ANXA5 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17223	Anxa5 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23676	Anxa5 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Anxa5	NCBI	NCBI:308
Mus musculus	Anxa5	NCBI	NCBI:11747

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