Igfbp2 - insulin-like growth factor binding protein 2 Gene

Rattus norvegicus

Also known as IBP-2; BRL-BP; IGFBP-2; ILGFBPA

Gene ID: 25662 | Gene type: protein coding

About Igfbp2

Summary

Enables insulin-like growth factor I binding activity and insulin-like growth factor II binding activity. Involved in several processes, including response to estradiol; response to estrogen; and response to retinoic acid. Located in apical plasma membrane; cytoplasmic vesicle; and extracellular space. Biomarker of hypertension and hypothyroidism. Human ortholog(s) of this gene implicated in obesity. Orthologous to human IGFBP2 (Insulin like growth factor binding protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Igfbp2 Products(1)

mRNA	Protein	Name
NM_013122.2	NP_037254.2	insulin-like growth factor-binding protein 2 precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables insulin-like growth factor I binding	IDA IDA: Inferred from direct assay	2538475	RGD
enables insulin-like growth factor I binding	IMP IMP: Inferred from mutant phenotype	2538475	RGD
enables insulin-like growth factor II binding	IDA IDA: Inferred from direct assay	1709938	RGD
enables insulin-like growth factor II binding	IPI IPI: Inferred from physical interaction	2538475	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to hormone stimulus	IEP IEP: Inferred from expression pattern	16720626	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	17123939	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	10842239	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	12801995	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	15705658	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	17308996	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	15576465	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	7536658	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	11880314	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	10842239	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	15613074	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	10842239	RGD
located in extracellular region	IDA IDA: Inferred from direct assay	2426267	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	2538475	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

insulin-like growth factor-binding protein 2

IGF-binding protein 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS06625	IGFBP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS16821	Igfbp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23261	Igfbp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991042	Anti-IGFBP2 Antibody (M14)	Antagonist	≥99.0%	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Igfbp2	NCBI	NCBI:3485
Macaca fascicularis	Igfbp2	NCBI	NCBI:102131255
Mus musculus	Igfbp2	NCBI	NCBI:16008

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