Pcmt1 - protein-L-isoaspartate (D-aspartate) O-methyltransferase 1 Gene

Rattus norvegicus

Also known as PCM

Gene ID: 25604 | Gene type: protein coding

About Pcmt1

Summary

Enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity. Involved in several processes, including S-adenosylhomocysteine metabolic process; negative regulation of cardiac muscle cell apoptotic process; and response to ethanol. Located in several cellular components, including basolateral plasma membrane; brush border membrane; and perikaryon. Biomarker of high grade glioma. Orthologous to human PCMT1 (protein-L-isoaspartate (D-aspartate) O-methyltransferase). [provided by Alliance of Genome Resources, Apr 2022]

Pcmt1 Products(3)

mRNA	Protein	Name
NM_001398561.1	NP_001385490.1	protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform a
NM_001398562.1	NP_001385491.1	protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform c
NM_013073.4	NP_037205.3	protein-L-isoaspartate(D-aspartate) O-methyltransferase isoform b

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables S-adenosylmethionine-dependent methyltransferase activity	IDA IDA: Inferred from direct assay	8263531	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	23647599	RGD
enables protein-L-isoaspartate (D-aspartate) O-methyltransferase activity	IDA IDA: Inferred from direct assay	8263531	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in S-adenosylhomocysteine metabolic process	IDA IDA: Inferred from direct assay	8263531	RGD
involved in S-adenosylmethionine metabolic process	IDA IDA: Inferred from direct assay	8263531	RGD
involved in cellular response to hypoxia	IEP IEP: Inferred from expression pattern	23647599	RGD
involved in negative regulation of cardiac muscle cell apoptotic process	IMP IMP: Inferred from mutant phenotype	23647599	RGD
involved in protein methylation	IDA IDA: Inferred from direct assay	1886138	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	17336420	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	7639720	RGD
located in brush border membrane	IDA IDA: Inferred from direct assay	7639720	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	9188065	RGD
located in perikaryon	IDA IDA: Inferred from direct assay	7783974	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

protein-L-isoaspartate(D-aspartate) O-methyltransferase

L-isoaspartyl protein carboxyl methyltransferase	PIMT
protein L-isoaspartyl/D-aspartyl methyltransferase	protein-beta-aspartate methyltransferase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS10157	PCMT1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS21683	Pcmt1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS28201	Pcmt1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Pcmt1	NCBI	NCBI:5110

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