Map2 - microtubule-associated protein 2 Gene

Rattus norvegicus

Also known as MAP2R; Mtap2

Gene ID: 25595 | Gene type: protein coding

About Map2

Summary

Enables actin binding activity; microtubule binding activity; and protein kinase binding activity. Involved in several processes, including negative regulation of cellular component organization; positive regulation of vesicle transport along microtubule; and response to progesterone. Located in several cellular components, including axon; dendrite; and endoplasmic reticulum. Part of protein-containing complex. Used to study Alzheimer's disease and cerebral infarction. Biomarker of arteriovenous malformation; asphyxia neonatorum; brain ischemia; sciatic neuropathy; and temporal lobe epilepsy. Orthologous to human MAP2 (microtubule associated protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Map2 Products(1)

mRNA	Protein	Name
NM_013066.1	NP_037198.1	microtubule-associated protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables actin binding	IMP IMP: Inferred from mutant phenotype	11029056	RGD
enables microtubule binding	IMP IMP: Inferred from mutant phenotype	11029056	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15623521	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	2561973	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of axon extension	IMP IMP: Inferred from mutant phenotype	28426968	RGD
involved in negative regulation of microtubule depolymerization	IMP IMP: Inferred from mutant phenotype	11029056	RGD
involved in negative regulation of microtubule polymerization	IMP IMP: Inferred from mutant phenotype	28426968	RGD
involved in positive regulation of anterograde dense core granule transport	IMP IMP: Inferred from mutant phenotype	28426968	RGD
involved in positive regulation of anterograde synaptic vesicle transport	IMP IMP: Inferred from mutant phenotype	28426968	RGD
involved in regulation of organelle transport along microtubule	IMP IMP: Inferred from mutant phenotype	28426968	RGD
involved in regulation of protein localization	IMP IMP: Inferred from mutant phenotype	28426968	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	21683086	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	21683086	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in actin cytoskeleton	IMP IMP: Inferred from mutant phenotype	11029056	RGD
located in apical distal dendrite	IDA IDA: Inferred from direct assay	3517689	RGD
located in axon hillock	IDA IDA: Inferred from direct assay	3517689	RGD
located in axon initial segment	IDA IDA: Inferred from direct assay	28426968	RGD
located in basal dendrite	IDA IDA: Inferred from direct assay	3517689	RGD
located in cytoplasm	IDA IDA: Inferred from direct assay	2509111	RGD
located in cytoplasm	IMP IMP: Inferred from mutant phenotype	11029056	RGD
located in dendrite	IDA IDA: Inferred from direct assay	10712642	RGD
located in dendrite cytoplasm	IDA IDA: Inferred from direct assay	3517689	RGD
located in dendritic branch	IDA IDA: Inferred from direct assay	3835499	RGD
located in dendritic filopodium	IDA IDA: Inferred from direct assay	3517689	RGD
located in dendritic growth cone	IDA IDA: Inferred from direct assay	3517689	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	3835499	RGD
located in distal dendrite	IDA IDA: Inferred from direct assay	3835499	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	2743390	RGD
NOT located in main axon	IDA IDA: Inferred from direct assay	3517689	RGD
located in microtubule cytoskeleton	IMP IMP: Inferred from mutant phenotype	11029056	RGD
located in neuron projection	IDA IDA: Inferred from direct assay	21119615	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	3835499	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	2743390	RGD
located in primary dendrite	IDA IDA: Inferred from direct assay	3835499	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	15623521	RGD
located in proximal dendrite	IDA IDA: Inferred from direct assay	3835499	RGD
located in proximal neuron projection	IDA IDA: Inferred from direct assay	28426968	RGD
located in ruffle membrane	IMP IMP: Inferred from mutant phenotype	11029056	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

microtubule-associated protein 2

MAP-2

microtubule-associated protein 2C

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-107116	MAP4343		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (32)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-136848	SM1-71	Inhibitor	96.09%	Unkown
HY-159190	HRX-0233	Inhibitor	98.92%	Unkown
HY-RS16235	Map2k4 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-171178	DK2403		98.24%	Unkown
HY-RS08350	METAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-107116S	MAP4343-d4		/	Unkown
HY-163880	EGFR-IN-119	Inhibitor	/	Unkown
HY-168857	GSK-3β inhibitor 24		/	Unkown
HY-P3894	P34cdc2 Kinase Fragment	Modulator	/	Unkown
HY-RS08032	MAP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08033	MAP2K1 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08034	Map2k1 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08035	Map2k1 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS08036	MAP2K2 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08037	Map2k2 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08038	Map2k2 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS08039	MAP2K3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08040	MAP2K4 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08041	MAP2K5 Human Pre-designed siRNA Set A		/	Unkown
HY-RS08042	Map2k5 Mouse Pre-designed siRNA Set A		/	Unkown
HY-RS08043	Map2k5 Rat Pre-designed siRNA Set A		/	Unkown
HY-RS08044	MAP2K6 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08045	MAP2K7 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS08160	MASP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-D2415	BODIPY-FL staurosporine		/	Unkown
HY-RS17292	Map2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17782	Map2k6 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18959	Neu1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19790	Map2k7 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23747	Map2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24249	Map2k6 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS26286	Map2k7 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Map2	NCBI	NCBI:4133
Mus musculus	Map2	NCBI	NCBI:17756

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