Star - steroidogenic acute regulatory protein Gene

Rattus norvegicus

Gene ID: 25557 | Gene type: protein coding

About Star

Summary

Predicted to enable Cholesterol binding activity. Involved in several processes, including cellular response to organonitrogen compound; response to glucocorticoid; and steroid biosynthetic process. Located in several cellular components, including cytosol; mitochondrial envelope; and neuronal cell body. Biomarker of hypogonadism; hypothyroidism; nephrosis; polycystic ovary syndrome; and type 2 diabetes mellitus. Human ortholog(s) of this gene implicated in congenital adrenal hyperplasia. Orthologous to human STAR (steroidogenic acute regulatory protein). [provided by Alliance of Genome Resources, Apr 2022]

Star Products(1)

mRNA	Protein	Name
NM_031558.3	NP_113746.1	steroidogenic acute regulatory protein, mitochondrial precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables protein binding	IPI IPI: Inferred from physical interaction	12925534	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in bile acid biosynthetic process	IDA IDA: Inferred from direct assay	15382124	RGD
involved in biphenyl metabolic process	IEP IEP: Inferred from expression pattern	19071209	RGD
involved in cellular response to alkaloid	IEP IEP: Inferred from expression pattern	19639602	RGD
involved in cellular response to antibiotic	IEP IEP: Inferred from expression pattern	18655822	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	9832418	RGD
involved in cellular response to cadmium ion	IEP IEP: Inferred from expression pattern	17719163	RGD
involved in cellular response to dexamethasone stimulus	IEP IEP: Inferred from expression pattern	20075416	RGD
involved in cellular response to epinephrine stimulus	IEP IEP: Inferred from expression pattern	11064152	RGD
involved in cellular response to fibroblast growth factor stimulus	IEP IEP: Inferred from expression pattern	17494997	RGD
involved in cellular response to follicle-stimulating hormone stimulus	IEP IEP: Inferred from expression pattern	20810564	RGD
involved in cellular response to glucose stimulus	IEP IEP: Inferred from expression pattern	18353182	RGD
involved in cellular response to gonadotropin stimulus	IEP IEP: Inferred from expression pattern	11172811	RGD
involved in cellular response to growth hormone stimulus	IEP IEP: Inferred from expression pattern	10098503	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	17023532	RGD
involved in cellular response to interferon-alpha	IMP IMP: Inferred from mutant phenotype	19929576	RGD
involved in cellular response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	20665543	RGD
involved in cellular response to luteinizing hormone stimulus	IEP IEP: Inferred from expression pattern	17241129	RGD
involved in cellular response to metal ion	IEP IEP: Inferred from expression pattern	18602937	RGD
involved in cellular response to organic cyclic compound	IEP IEP: Inferred from expression pattern	20937274	RGD
involved in cellular response to transforming growth factor beta stimulus	IEP IEP: Inferred from expression pattern	18511507	RGD
involved in cellular response to type II interferon	IEP IEP: Inferred from expression pattern	9564825	RGD
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	19190255	RGD
involved in dibenzo-p-dioxin metabolic process	IEP IEP: Inferred from expression pattern	18637154	RGD
involved in diterpenoid metabolic process	IEP IEP: Inferred from expression pattern	11064152	RGD
involved in estrogen biosynthetic process	IMP IMP: Inferred from mutant phenotype	16579833	RGD
involved in insecticide metabolic process	IEP IEP: Inferred from expression pattern	18401575	RGD
involved in intracellular cholesterol transport	IEP IEP: Inferred from expression pattern	14617579	RGD
involved in male gonad development	IEP IEP: Inferred from expression pattern	18772241	RGD
involved in negative regulation of neuron apoptotic process	IMP IMP: Inferred from mutant phenotype	16579833	RGD
involved in organic acid metabolic process	IEP IEP: Inferred from expression pattern	17400581	RGD
involved in phenol-containing compound metabolic process	IEP IEP: Inferred from expression pattern	18191889	RGD
involved in phthalate metabolic process	IEP IEP: Inferred from expression pattern	16809437	RGD
involved in positive regulation of gene expression	IMP IMP: Inferred from mutant phenotype	19156851	RGD
involved in positive regulation of neurogenesis	IMP IMP: Inferred from mutant phenotype	16579833	RGD
involved in regulation of neuronal synaptic plasticity	IMP IMP: Inferred from mutant phenotype	16673174	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	20393161	RGD
involved in response to benzoic acid	IEP IEP: Inferred from expression pattern	30476341	RGD
involved in response to corticosterone	IEP IEP: Inferred from expression pattern	18335507	RGD
involved in response to estrogen	IEP IEP: Inferred from expression pattern	19734697	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	16930210	RGD
involved in response to fungicide	IEP IEP: Inferred from expression pattern	16214947	RGD
involved in response to gonadotropin	IEP IEP: Inferred from expression pattern	19929576	RGD
involved in response to herbicide	IEP IEP: Inferred from expression pattern	20667998	RGD
involved in response to hydrogen peroxide	IEP IEP: Inferred from expression pattern	14635199	RGD
involved in response to insecticide	IEP IEP: Inferred from expression pattern	19892000	RGD
involved in response to ionizing radiation	IEP IEP: Inferred from expression pattern	18821396	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	14514953	RGD
involved in response to leptin	IEP IEP: Inferred from expression pattern	11604238	RGD
involved in response to nicotine	IEP IEP: Inferred from expression pattern	20498001	RGD
involved in response to nutrient	IEP IEP: Inferred from expression pattern	16882930	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	19190255	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	16737795	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	18609294	RGD
involved in response to retinoic acid	IEP IEP: Inferred from expression pattern	30476341	RGD
involved in response to steroid hormone	IEP IEP: Inferred from expression pattern	19961867	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	20610472	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	16777379	RGD
involved in testosterone biosynthetic process	IEP IEP: Inferred from expression pattern	19883722	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in mitochondrial crista	IDA IDA: Inferred from direct assay	9065457	RGD
located in neuronal cell body	IDA IDA: Inferred from direct assay	19730783	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

steroidogenic acute regulatory protein, mitochondrial

START domain-containing protein 1

stARD1

Related Agents

Pre-clinical Phase

Bioactive Molecules (17)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-15483	DY131		99.72%	Unkown
HY-Y0740	4-Methoxybenzaldehyde		99.67%	Unkown
HY-D1208	CDP-Star		95.30%	Unkown
HY-143656	SH379		/	Unkown
HY-161384	WJM-715	Inhibitor	/	Unkown
HY-N12102	Dihydrodehydrodiconiferyl alcohol 9-O-α-L-rhamnopyranoside	Inhibitor	/	Unkown
HY-N12136	1α-Hydroxy-3-deoxypseudoanisatin		/	Unkown
HY-P10780	RFRP-3 (mouse)		/	Unkown
HY-RS02193	CD163L1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS05921	GUCY2C Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS13875	STAR Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-W750726	7,8,7’,8’-Tetradehydroastaxanthin		/	Unkown
HY-Y0740S	4-Methoxybenzaldehyde-d1		/	Unkown
HY-Y0740S1	4-Methoxybenzaldehyde-d3		/	Unkown
HY-RS18153	Star Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS24627	Star Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-Y0740S2	4-Methoxybenzaldehyde-d2		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Star	NCBI	NCBI:6770
Canis familiaris	Star	NCBI	NCBI:475588
Macaca fascicularis	Star	NCBI	NCBI:102132972
Mus musculus	Star	NCBI	NCBI:20845

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