Scp2 - sterol carrier protein 2 Gene

Rattus norvegicus

Also known as SCPx; NSLIPTR

Gene ID: 25541 | Gene type: protein coding

About Scp2

Summary

Enables C-acyltransferase activity; identical protein binding activity; and lipid transfer activity. Involved in several processes, including cellular response to cholesterol; monocarboxylic acid metabolic process; and positive regulation of Cholesterol biosynthetic process. Located in several cellular components, including endoplasmic reticulum; mitochondrion; and peroxisomal matrix. Is extrinsic component of mitochondrial outer membrane. Orthologous to human SCP2 (sterol carrier protein 2). [provided by Alliance of Genome Resources, Apr 2022]

Scp2 Products(1)

mRNA	Protein	Name
NM_138508.5	NP_612517.3	sterol carrier protein 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables acetyl-CoA C-acyltransferase activity	IDA IDA: Inferred from direct assay	8063752	RGD
enables acetyl-CoA C-myristoyltransferase activity	IDA IDA: Inferred from direct assay	9325339	RGD
enables cholesterol transfer activity	IDA IDA: Inferred from direct assay	8063752	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	10733876	RGD
enables phosphatidylcholine transfer activity	IDA IDA: Inferred from direct assay	8063752	RGD
enables phosphatidylethanolamine transfer activity	IDA IDA: Inferred from direct assay	8606365	RGD
enables propionyl-CoA C2-trimethyltridecanoyltransferase activity	IDA IDA: Inferred from direct assay	9245689	RGD
enables protein-containing complex binding	IDA IDA: Inferred from direct assay	10733876	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in bile acid metabolic process	IDA IDA: Inferred from direct assay	9325339	RGD
involved in cellular response to cholesterol	IEP IEP: Inferred from expression pattern	7989577	RGD
involved in fatty acid beta-oxidation	IDA IDA: Inferred from direct assay	9325339	RGD
involved in positive regulation of apoptotic process	IDA IDA: Inferred from direct assay	16772292	RGD
involved in positive regulation of cholesterol biosynthetic process	IDA IDA: Inferred from direct assay	2554812	RGD
involved in positive regulation of cholesterol import	IDA IDA: Inferred from direct assay	16772292	RGD
involved in positive regulation of steroid biosynthetic process	IDA IDA: Inferred from direct assay	1703300	RGD
involved in positive regulation of steroid biosynthetic process	IMP IMP: Inferred from mutant phenotype	3030719	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	2474437	RGD
involved in response to luteinizing hormone	IEP IEP: Inferred from expression pattern	2249635	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in peroxisomal matrix	IDA IDA: Inferred from direct assay	8063752	RGD
located in peroxisome	IDA IDA: Inferred from direct assay	9325339	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

sterol carrier protein 2

NSL-TP	SCP-2
SCP-2/3-oxoacyl-CoA thiolase	SCP-2/thiolase
SCP-X	SCP-chi
Sterol carrier protein 2, liver	acetyl-CoA C-myristoyltransferase
non-specific lipid-transfer protein	propanoyl-CoA C-acyltransferase
sterol carrier protein X	straight-chain

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-124824	Methyl gerfelin	Inhibitor	/	Unkown
HY-RS03292	CTDSP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS12559	SCP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS14071	SYCP2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20817	Scp2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27331	Scp2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Scp2	NCBI	NCBI:6342

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