2. Gene
  3. Ppia - peptidylprolyl isomerase A Gene

Ppia - peptidylprolyl isomerase A Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as CYCA; CyP-A

Gene ID: 25518 | Gene type: protein coding

About Ppia

Summary

Enables cyclosporin A binding activity. Involved in negative regulation of phosphoprotein Phosphatase activity. Predicted to be located in cytosol; extracellular region; and nucleus. Predicted to be part of protein-containing complex. Predicted to be active in cytoplasm and intracellular membrane-bounded organelle. Used to study epilepsy. Human ortholog(s) of this gene implicated in cholangiocarcinoma and human immunodeficiency virus infectious disease. Orthologous to human PPIA (peptidylprolyl isomerase A). [provided by Alliance of Genome Resources, Apr 2022]

Ppia Products(1)

mRNA Protein Name
NM_017101.1 NP_058797.1 peptidyl-prolyl cis-trans isomerase A
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables cyclosporin A binding IDA
IDA: Inferred from direct assay
19832699 RGD
Biological Process GO Annotation Evidence Reference Source
involved in negative regulation of calcineurin-mediated signaling IDA
IDA: Inferred from direct assay
19832699 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

peptidyl-prolyl cis-trans isomerase A

PPIase A

cyclophilin A

cyclosporin A-binding protein

p1B15

p31

rotamase A

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-172209 PPIA-IN-1 / Unkown
HY-RS10946 PPIA Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18045 Ppia Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24519 Ppia Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ppia NCBI NCBI:5478
Mus musculus Ppia NCBI NCBI:268373