2. Gene
  3. P4hb - prolyl 4-hydroxylase subunit beta Gene

P4hb - prolyl 4-hydroxylase subunit beta Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as PDI; PDIR

Gene ID: 25506 | Gene type: protein coding

About P4hb

Summary

Enables enzyme binding activity and protein disulfide isomerase activity. Predicted to be involved in several processes, including positive regulation of substrate adhesion-dependent cell spreading; positive regulation of viral entry into host cell; and protein folding in endoplasmic reticulum. Predicted to act upstream of or within cellular response to interleukin-7 and peptidyl-proline hydroxylation to 4-hydroxy-L-proline. Predicted to be located in several cellular components, including cytosol; endoplasmic reticulum-Golgi intermediate compartment; and lamellipodium. Predicted to be part of endoplasmic reticulum chaperone complex and procollagen-proline 4-dioxygenase complex. Predicted to be active in endoplasmic reticulum and external side of plasma membrane. Human ortholog(s) of this gene implicated in Cole-Carpenter syndrome. Orthologous to human P4HB (prolyl 4-hydroxylase subunit beta). [provided by Alliance of Genome Resources, Apr 2022]

P4hb Products(1)

mRNA Protein Name
NM_012998.2 NP_037130.2 protein disulfide-isomerase precursor
Gene Ontology
  • Molecular Function
Molecular Function GO Annotation Evidence Reference Source
enables enzyme binding IPI
IPI: Inferred from physical interaction
23061969 RGD
enables protein disulfide isomerase activity IMP
IMP: Inferred from mutant phenotype
2841089 RGD
enables protein-containing complex binding IPI
IPI: Inferred from physical interaction
11830580 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

protein disulfide-isomerase

Protein disulfide isomerase (Prolyl 4-hydroxylase, beta polypeptide)

cellular thyroid hormone-binding protein

prolyl 4-hydroxylase, beta polypeptide

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS09945 P4HB Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18780 P4hb Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25269 P4hb Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens P4hb NCBI NCBI:5034
Mus musculus P4hb NCBI NCBI:18453