Lhcgr - luteinizing hormone/choriogonadotropin receptor Gene

Rattus norvegicus

Also known as Lhr; LSHR; LSH-R; LH/CG-R

Gene ID: 25477 | Gene type: protein coding

About Lhcgr

Summary

Enables several functions, including ATPase binding activity; identical protein binding activity; and peptide hormone binding activity. Involved in several processes, including G protein-coupled receptor signaling pathway; activation of Adenylate Cyclase activity; and arachidonic acid secretion. Located in several cellular components, including endoplasmic reticulum; endosome; and lysosome. Is integral component of plasma membrane and intrinsic component of external side of plasma membrane. Part of receptor complex. Human ortholog(s) of this gene implicated in Leydig cell hypoplasia; Leydig cell tumor; breast cancer; familial male-limited precocious puberty; and gonadal disease. Orthologous to human LHCGR (luteinizing hormone/choriogonadotropin receptor). [provided by Alliance of Genome Resources, Apr 2022]

Lhcgr Products(1)

mRNA	Protein	Name
NM_012978.2	NP_037110.1	lutropin-choriogonadotropic hormone receptor precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables ATPase binding	IPI IPI: Inferred from physical interaction	17588601	RGD
enables G protein-coupled peptide receptor activity	IDA IDA: Inferred from direct assay	2502842	RGD
enables identical protein binding	IDA IDA: Inferred from direct assay	11266505	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	2601325	RGD
enables peptide hormone binding	IDA IDA: Inferred from direct assay	15901736	RGD
enables peptide hormone binding	IMP IMP: Inferred from mutant phenotype	1714448	RGD
enables peptide hormone binding	IPI IPI: Inferred from physical interaction	2601325	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in activation of adenylate cyclase activity	IDA IDA: Inferred from direct assay	8440169	RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	2502842	RGD
involved in adenylate cyclase-modulating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	1714448	RGD
involved in arachidonate secretion	IDA IDA: Inferred from direct assay	9291830	RGD
involved in hormone-mediated signaling pathway	IDA IDA: Inferred from direct assay	2502842	RGD
involved in luteinizing hormone signaling pathway	IDA IDA: Inferred from direct assay	3030841	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	3026357	RGD
involved in positive regulation of calcium ion transport into cytosol	IDA IDA: Inferred from direct assay	8187959	RGD
involved in positive regulation of calcium-mediated signaling	IDA IDA: Inferred from direct assay	8187959	RGD
involved in positive regulation of hormone biosynthetic process	IDA IDA: Inferred from direct assay	3026357	RGD
involved in positive regulation of release of sequestered calcium ion into cytosol	IDA IDA: Inferred from direct assay	8187959	RGD
involved in protein targeting to lysosome	IMP IMP: Inferred from mutant phenotype	10847593	RGD
involved in regulation of steroid biosynthetic process	IEP IEP: Inferred from expression pattern	17241129	RGD
involved in response to luteinizing hormone	IDA IDA: Inferred from direct assay	9553128	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	9653071	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in endosome	IDA IDA: Inferred from direct assay	10847593	RGD
located in extracellular space	IDA IDA: Inferred from direct assay	2174034	RGD
part of receptor complex	IDA IDA: Inferred from direct assay	11266505	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

lutropin-choriogonadotropic hormone receptor

LH receptor	LH/CG receptor
luteinizing hormone receptor	luteinizing hormone/chorionic gonadotropin receptor

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-150210	FSHR agonist 1	Agonist	98.48%	Unkown
HY-100271	Org41841	Agonist	99.77%	Unkown
HY-P10594	Myr-Arf1(2–17)		/	Unkown
HY-RS07624	LHCGR Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17915	Lhcgr Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24384	Lhcgr Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Lhcgr	NCBI	NCBI:3973

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