Fosl2 - FOS like 2, AP-1 transcription factor subunit Gene

Rattus norvegicus

Also known as Fra2

Gene ID: 25446 | Gene type: protein coding

About Fosl2

Summary

Enables DNA-binding transcription factor activity and transcription cis-regulatory region binding activity. Involved in several processes, including conditioned taste aversion; response to estradiol; and response to progesterone. Located in nucleus. Biomarker of renal carcinoma. Orthologous to human FOSL2 (FOS like 2, AP-1 transcription factor subunit). [provided by Alliance of Genome Resources, Apr 2022]

Fosl2 Products(2)

mRNA	Protein	Name
NM_001013146.2	NP_001013164.1	fos-related antigen 2 isoform 2
NM_012954.2	NP_037086.2	fos-related antigen 2 isoform 1

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA binding	IDA IDA: Inferred from direct assay	12358739	RGD
enables DNA-binding transcription factor activity	IMP IMP: Inferred from mutant phenotype	10830307	RGD
enables double-stranded DNA binding	IDA IDA: Inferred from direct assay	10830307	RGD
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	10830307	RGD
enables transcription cis-regulatory region binding	IDA IDA: Inferred from direct assay	21367864	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in circadian rhythm	IEP IEP: Inferred from expression pattern	10987819	RGD
involved in conditioned taste aversion	IEP IEP: Inferred from expression pattern	18374904	RGD
involved in female pregnancy	IEP IEP: Inferred from expression pattern	12080023	RGD
involved in photoperiodism	IEP IEP: Inferred from expression pattern	16962714	RGD
involved in positive regulation of DNA-templated transcription	IDA IDA: Inferred from direct assay	11340164	RGD
involved in response to cAMP	IEP IEP: Inferred from expression pattern	18280640	RGD
involved in response to cytokine	IEP IEP: Inferred from expression pattern	18280640	RGD
involved in response to estradiol	IMP IMP: Inferred from mutant phenotype	12021174	RGD
involved in response to hypoxia	IMP IMP: Inferred from mutant phenotype	15892448	RGD
involved in response to immobilization stress	IEP IEP: Inferred from expression pattern	17936518	RGD
involved in response to light stimulus	IEP IEP: Inferred from expression pattern	11146118	RGD
involved in response to mechanical stimulus	IEP IEP: Inferred from expression pattern	16373449	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	11113530	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	10934195	RGD
involved in response to progesterone	IEP IEP: Inferred from expression pattern	12080023	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	11295234	RGD
involved in transcription by RNA polymerase II	IMP IMP: Inferred from mutant phenotype	10830307	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

fos-related antigen 2

FOS like 2, AP-1 trancription factor subunit	FRA-2
fos-like antigen 2

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS05035	FOSL2 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS18065	Fosl2 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24540	Fosl2 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Fosl2	NCBI	NCBI:2355

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