Eef2k - eukaryotic elongation factor-2 kinase Gene

Rattus norvegicus

Also known as SMEF2K

Gene ID: 25435 | Gene type: protein coding

About Eef2k

Summary

Enables elongation factor-2 kinase activity. Involved in several processes, including cellular response to anoxia; positive regulation of cellular component organization; and response to peptide hormone. Located in dendritic spine and postsynaptic density. Orthologous to human EEF2K (eukaryotic elongation factor 2 kinase). [provided by Alliance of Genome Resources, Apr 2022]

Eef2k Products(1)

mRNA	Protein	Name
NM_012947.3	NP_037079.1	eukaryotic elongation factor 2 kinase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables elongation factor-2 kinase activity	IMP IMP: Inferred from mutant phenotype	8663182	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to anoxia	IEP IEP: Inferred from expression pattern	12194824	RGD
involved in cellular response to brain-derived neurotrophic factor stimulus	IEP IEP: Inferred from expression pattern	19625250	RGD
involved in cellular response to cAMP	IEP IEP: Inferred from expression pattern	9841860	RGD
involved in cellular response to calcium ion	IEP IEP: Inferred from expression pattern	19188248	RGD
involved in cellular response to insulin stimulus	IEP IEP: Inferred from expression pattern	9841860	RGD
involved in negative regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	16227605	RGD
involved in positive regulation of dendritic spine morphogenesis	IMP IMP: Inferred from mutant phenotype	20427644	RGD
involved in positive regulation of endocytosis	IMP IMP: Inferred from mutant phenotype	18045921	RGD
involved in positive regulation of synapse assembly	IMP IMP: Inferred from mutant phenotype	20427644	RGD
involved in regulation of translation at postsynapse	IDA IDA: Inferred from direct assay	20427644	RGD
involved in regulation of translation at postsynapse	IEP IEP: Inferred from expression pattern	20427644	RGD
involved in regulation of translation at postsynapse	IMP IMP: Inferred from mutant phenotype	20427644	RGD
involved in response to ischemia	IEP IEP: Inferred from expression pattern	12920134	RGD
involved in response to prolactin	IEP IEP: Inferred from expression pattern	8126003	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in dendritic spine	IDA IDA: Inferred from direct assay	12711090	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	12711090	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	20427644	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	12711090	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

eukaryotic elongation factor 2 kinase

calcium/calmodulin-dependent eukaryotic elongation factor 2 kinase	eEF-2 kinase
eEF-2K	elongation factor 2 kinase
eukaroytic elongation factor 2 kinase

Related Agents

Pre-clinical Phase

Bioactive Molecules (10)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-110096	A-484954	Inhibitor	99.34%	Unkown
HY-100576	NH125	Inhibitor	99.63%	Unkown
HY-146324	PROTAC eEF2K degrader-1	Activator	98.64%	Unkown
HY-112393	TX-1918	Inhibitor	/	Unkown
HY-121828	TX-1123	Inhibitor	/	Unkown
HY-123024	Cefatrizine		/	Unkown
HY-176149	Fluoxetine-Conjugated Platinum(IV) prodrug-1		/	Unkown
HY-RS04181	EEF2K Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS20013	Eef2k Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS26516	Eef2k Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Eef2k	NCBI	NCBI:29904

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