Cyp7a1 - cytochrome P450 family 7 subfamily A member 1 Gene

Rattus norvegicus

Also known as CHAP; CYP7; CYP7S1

Gene ID: 25428 | Gene type: protein coding

About Cyp7a1

Summary

Enables Cholesterol 7-alpha-monooxygenase activity. Involved in several processes, including bile acid biosynthetic process; cellular response to cholesterol; and regulation of lipid biosynthetic process. Located in intracellular membrane-bounded organelle. Biomarker of alcoholic hepatitis; cholestasis; extrahepatic cholestasis; and non-alcoholic steatohepatitis. Orthologous to human CYP7A1 (Cytochrome P450 family 7 subfamily A member 1). [provided by Alliance of Genome Resources, Apr 2022]

Cyp7a1 Products(1)

mRNA	Protein	Name
NM_012942.2	NP_037074.1	cytochrome P450 7A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables cholesterol 7-alpha-monooxygenase activity	IDA IDA: Inferred from direct assay	1694852	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in bile acid and bile salt transport	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in bile acid biosynthetic process	IDA IDA: Inferred from direct assay	1694852	RGD
involved in cellular response to cholesterol	IDA IDA: Inferred from direct assay	1694852	RGD
involved in cholesterol catabolic process	IDA IDA: Inferred from direct assay	1694852	RGD
involved in cholesterol homeostasis	IDA IDA: Inferred from direct assay	1694852	RGD
involved in negative regulation of collagen biosynthetic process	IMP IMP: Inferred from mutant phenotype	15521018	RGD
involved in negative regulation of fatty acid biosynthetic process	IDA IDA: Inferred from direct assay	23536474	RGD
involved in positive regulation of cholesterol biosynthetic process	IDA IDA: Inferred from direct assay	23536474	RGD
involved in regulation of bile acid biosynthetic process	IDA IDA: Inferred from direct assay	1694852	RGD
involved in response to ethanol	IEP IEP: Inferred from expression pattern	27939985	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	27939985	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in intracellular membrane-bounded organelle	IDA IDA: Inferred from direct assay	1694852	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

cytochrome P450 7A1

24-hydroxycholesterol 7-alpha-hydroxylase	CYPVII
cholesterol 7-alpha-hydroxylase	cholesterol 7-alpha-monooxygenase
cytochrome P450 (cholesterol hydroxylase 7 alpha)	cytochrome P450, 7a1
cytochrome P450, family 7, subfamily a, polypeptide 1

Related Agents

Clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Phase
HY-19264	264W94		/	Phase 2

Pre-clinical Phase

Bioactive Molecules (13)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-113259	7α-Hydroxy-4-cholesten-3-one		99.60%	Unkown
HY-117147A	GSK2945 hydrochloride	Activator	99.69%	Unkown
HY-W008226	Phloracetophenone		99.96%	Unkown
HY-163436	F44-A13		96.73%	Unkown
HY-117147	GSK2945	Activator	/	Unkown
HY-RS03487	CYP7A1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-168331	FXR agonist 10	Agonist	/	Unkown
HY-RS03488	CYP7B1 Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-N13218	Pueraria Extract		/	Unkown
HY-RS17211	Cyp7a1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS18706	Cyp7b1 Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23663	Cyp7a1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS25193	Cyp7b1 Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cyp7a1	NCBI	NCBI:1581

Name
Email *

	Sorry, but the email address you supplied was invalid.