2. Gene
  3. Col2a1 - collagen type II alpha 1 chain Gene

Col2a1 - collagen type II alpha 1 chain Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as CG2A1A; COLLII

Gene ID: 25412 | Gene type: protein coding

About Col2a1

Summary

Predicted to enable several functions, including MHC class II protein binding activity; identical protein binding activity; and platelet-derived growth factor binding activity. Predicted to be an extracellular matrix structural constituent. Involved in several processes, including cartilage development; cellular response to hormone stimulus; and cellular response to mechanical stimulus. Located in collagen-containing extracellular matrix and cytoplasm. Used to study degenerative disc disease; hypothyroidism; and osteoarthritis. Biomarker of degenerative disc disease and osteonecrosis. Human ortholog(s) of this gene implicated in Stickler syndrome (multiple); bone disease (multiple); cleft palate; eye disease (multiple); and multiple epiphyseal dysplasia with myopia and deafness. Orthologous to human COL2A1 (Collagen type II alpha 1 chain). [provided by Alliance of Genome Resources, Apr 2022]

Col2a1 Products(3)

mRNA Protein Name
NM_001414896.1 NP_001401825.1 collagen alpha-1(II) chain isoform 1 precursor
NM_012929.2 NP_037061.2 collagen alpha-1(II) chain isoform 2 precursor
NM_012929.1 NP_037061.1 collagen alpha-1(II) chain precursor
Gene Ontology
  • Biological Process
  • Cellular Component
Biological Process GO Annotation Evidence Reference Source
involved in cartilage development IEP
IEP: Inferred from expression pattern
9822201 RGD
involved in cartilage development involved in endochondral bone morphogenesis IEP
IEP: Inferred from expression pattern
12924823 RGD
involved in cellular response to insulin-like growth factor stimulus IEP
IEP: Inferred from expression pattern
18595745 RGD
involved in cellular response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19725071 RGD
involved in cellular response to nicotine IEP
IEP: Inferred from expression pattern
22766705 RGD
involved in cellular response to parathyroid hormone stimulus IEP
IEP: Inferred from expression pattern
22750004 RGD
involved in cellular response to peptide hormone stimulus IEP
IEP: Inferred from expression pattern
11120880 RGD
involved in cellular response to retinoic acid IEP
IEP: Inferred from expression pattern
23810783 RGD
involved in cellular response to tumor necrosis factor IEP
IEP: Inferred from expression pattern
19144181 RGD
involved in cellular response to vitamin E IEP
IEP: Inferred from expression pattern
23722449 RGD
involved in chondrocyte differentiation IEP
IEP: Inferred from expression pattern
21627568 RGD
involved in growth plate cartilage development IEP
IEP: Inferred from expression pattern
20591638 RGD
involved in response to X-ray IEP
IEP: Inferred from expression pattern
17549535 RGD
involved in response to fibroblast growth factor IEP
IEP: Inferred from expression pattern
21147086 RGD
involved in response to mechanical stimulus IEP
IEP: Inferred from expression pattern
19242967 RGD
Cellular Component GO Annotation Evidence Reference Source
located in collagen-containing extracellular matrix IDA
IDA: Inferred from direct assay
7649371 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

collagen alpha-1(II) chain

Procollagen II alpha 1

alpha-1 type II collagen

collagen type II (Col2A1) gene, enhancer region

collagen, type II, alpha 1

procollagen, type II, alpha 1

Related Agents

Pre-clinical Phase
Bioactive Molecules (5)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108065A 3'-Sialyllactose sodium Inhibitor ≥98.0% Unkown
HY-RS02981 COL2A1 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-108065 3'-Sialyllactose Inhibitor / Unkown
HY-RS18559 Col2a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS25041 Col2a1 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Col2a1 NCBI NCBI:1280