Cd44 - CD44 molecule (Indian blood group) Gene

Rattus norvegicus

Also known as CD44A; METAA; RHAMM

Gene ID: 25406 | Gene type: protein coding

About Cd44

Summary

Enables epidermal growth factor receptor binding activity; phosphoprotein binding activity; and protein kinase binding activity. Involved in several processes, including blood vessel maturation; macrophage fusion; and positive regulation of neutrophil apoptotic process. Located in apical plasma membrane; basolateral plasma membrane; and nucleus. Part of protein-containing complex. Biomarker of borna disease and cholestasis. Human ortholog(s) of this gene implicated in breast carcinoma (multiple); carcinoma (multiple); and prostate Cancer. Orthologous to human CD44 (CD44 molecule (Indian blood group)). [provided by Alliance of Genome Resources, Apr 2022]

Cd44 Products(1)

mRNA	Protein	Name
NM_012924.3	NP_037056.3	CD44 antigen precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables epidermal growth factor receptor binding	IPI IPI: Inferred from physical interaction	21349584	RGD
enables phosphoprotein binding	IPI IPI: Inferred from physical interaction	11316791	RGD
enables protein binding	IPI IPI: Inferred from physical interaction	15659388	RGD
enables protein kinase binding	IPI IPI: Inferred from physical interaction	8103744	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in blood vessel maturation	IEP IEP: Inferred from expression pattern	15947460	RGD
involved in cell adhesion	IMP IMP: Inferred from mutant phenotype	16306150	RGD
involved in cell migration	IMP IMP: Inferred from mutant phenotype	16306150	RGD
involved in macrophage fusion	IMP IMP: Inferred from mutant phenotype	16195325	RGD
involved in neuron projection development	IMP IMP: Inferred from mutant phenotype	17760872	RGD
involved in positive regulation of neutrophil apoptotic process	IMP IMP: Inferred from mutant phenotype	11044212	RGD
involved in postsynapse organization	IDA IDA: Inferred from direct assay	27798233	RGD
involved in postsynapse organization	IMP IMP: Inferred from mutant phenotype	27798233	RGD
involved in regulation of cell growth	IDA IDA: Inferred from direct assay	11316791	RGD
involved in regulation of modification of postsynaptic structure	EXP EXP: Inferred from Experiment	27798233	RGD
involved in regulation of modification of postsynaptic structure	IDA IDA: Inferred from direct assay	27798233	RGD
involved in regulation of modification of postsynaptic structure	IMP IMP: Inferred from mutant phenotype	27798233	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	31966914	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	17105903	RGD
involved in response to vitamin A	IEP IEP: Inferred from expression pattern	16804311	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in apical plasma membrane	IDA IDA: Inferred from direct assay	16786159	RGD
located in basolateral plasma membrane	IDA IDA: Inferred from direct assay	16786159	RGD
located in cell surface	IDA IDA: Inferred from direct assay	31723344	RGD
is active in glutamatergic synapse	EXP EXP: Inferred from Experiment	27798233	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	27798233	RGD
is active in glutamatergic synapse	IMP IMP: Inferred from mutant phenotype	27798233	RGD
is active in postsynapse	IDA IDA: Inferred from direct assay	27798233	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	27798233	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	11316791	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

CD44 antigen

Cell surface glycoprotein CD44 (hyaluronate binding protein)	ECMR-III
GP90 lymphocyte homing/adhesion receptor	HUTCH-I
PGP-1	PGP-I
extracellular matrix receptor III	hermes antigen
hyaluronate receptor	phagocytic glycoprotein 1
phagocytic glycopr

Related Agents

Pre-clinical Phase

Inhibitory Antibodies (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P991559	Anti-CD44 Antibody	Inhibitor	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Cd44	NCBI	NCBI:960
Macaca fascicularis	Cd44	NCBI	NCBI:101867504
Mus musculus	Cd44	NCBI	NCBI:12505

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