Anxa1 - annexin A1 Gene

Rattus norvegicus

Also known as p35; Anx1

Gene ID: 25380 | Gene type: protein coding

About Anxa1

Summary

Enables several functions, including DNA/DNA annealing activity; double-stranded DNA helicase activity; and Phospholipase A2 inhibitor activity. Contributes to single-stranded DNA binding activity and single-stranded RNA binding activity. Involved in several processes, including estrous cycle; gland development; and peptide hormone secretion. Located in several cellular components, including extracellular space; mast cell granule; and mitochondrial membrane. Part of protein-containing complex. Is active in synaptic membrane. Used to study acute kidney failure; brain ischemia; pleurisy; and uveitis. Biomarker of several diseases, including carcinoma (multiple); cerebral infarction; eye disease (multiple); hyperthyroidism; and pulmonary fibrosis. Human ortholog(s) of this gene implicated in brain ischemia and pancreatic Cancer. Orthologous to human ANXA1 (annexin A1). [provided by Alliance of Genome Resources, Apr 2022]

Anxa1 Products(1)

mRNA	Protein	Name
NM_012904.2	NP_037036.1	annexin A1

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA/DNA annealing activity	IDA IDA: Inferred from direct assay	20655937	RGD
enables double-stranded DNA helicase activity	IDA IDA: Inferred from direct assay	20655937	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	8335093	RGD
enables phospholipase A2 inhibitor activity	IDA IDA: Inferred from direct assay	2969352	RGD
enables phospholipid binding	IDA IDA: Inferred from direct assay	17993484	RGD
contributes to single-stranded DNA binding	IDA IDA: Inferred from direct assay	10548514	RGD
enables single-stranded DNA binding	IDA IDA: Inferred from direct assay	20655937	RGD
contributes to single-stranded RNA binding	IDA IDA: Inferred from direct assay	10548514	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in DNA duplex unwinding	IDA IDA: Inferred from direct assay	20655937	RGD
involved in cell surface receptor signaling pathway	IDA IDA: Inferred from direct assay	12459455	RGD
involved in cellular response to glucocorticoid stimulus	IDA IDA: Inferred from direct assay	2936963	RGD
involved in cellular response to hydrogen peroxide	IMP IMP: Inferred from mutant phenotype	8607818	RGD
involved in endocrine pancreas development	IEP IEP: Inferred from expression pattern	7527053	RGD
involved in estrous cycle	IEP IEP: Inferred from expression pattern	17283243	RGD
involved in gliogenesis	IEP IEP: Inferred from expression pattern	9263577	RGD
involved in hepatocyte differentiation	IEP IEP: Inferred from expression pattern	11668598	RGD
involved in insulin secretion	IDA IDA: Inferred from direct assay	12459455	RGD
involved in negative regulation of phospholipase A2 activity	IDA IDA: Inferred from direct assay	2969352	RGD
involved in negative regulation of protein secretion	IMP IMP: Inferred from mutant phenotype	8559285	RGD
involved in positive regulation of apoptotic process	IMP IMP: Inferred from mutant phenotype	8607818	RGD
involved in positive regulation of prostaglandin biosynthetic process	IMP IMP: Inferred from mutant phenotype	8260938	RGD
involved in prolactin secretion	IMP IMP: Inferred from mutant phenotype	10830310	RGD
involved in prostate gland development	IEP IEP: Inferred from expression pattern	22911278	RGD
involved in response to X-ray	IEP IEP: Inferred from expression pattern	9269316	RGD
involved in response to estradiol	IEP IEP: Inferred from expression pattern	17283243	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	17283243	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	9022675	RGD
involved in response to interleukin-1	IEP IEP: Inferred from expression pattern	11311405	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	8300854	RGD
involved in response to peptide hormone	IEP IEP: Inferred from expression pattern	8828496	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	9416328	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	10489933	RGD
located in mast cell granule	IDA IDA: Inferred from direct assay	11005211	RGD
located in mitochondrial membrane	IDA IDA: Inferred from direct assay	10806526	RGD
part of protein-containing complex	IDA IDA: Inferred from direct assay	10548514	RGD
is active in synaptic membrane	IDA IDA: Inferred from direct assay	8335093	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

annexin A1

Annexin 1 (p35) (Lipocortin 1)	annexin I
annexin-1	calpactin II
calpactin-2	chromobindin-9
lipocortin 1	lipocortin I
phospholipase A2 inhibitory protein

Related Agents

Pre-clinical Phase

Bioactive Molecules (5)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00757	ANXA1 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-P10275	Tat-NTS peptide	Inhibitor	/	Unkown
HY-P10412	A11	Inhibitor	/	Unkown
HY-RS16647	Anxa1 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS23081	Anxa1 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Anxa1	NCBI	NCBI:301
Macaca fascicularis	Anxa1	NCBI	NCBI:102144835
Canis lupus familiaris	Anxa1	NCBI
Mus musculus	Anxa1	NCBI	NCBI:16952

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