Alad - aminolevulinate dehydratase Gene

Rattus norvegicus

Also known as ALADR; aminolevulinatedelta-dehydratase

Gene ID: 25374 | Gene type: protein coding

About Alad

Summary

Enables porphobilinogen synthase activity and Proteasome core complex binding activity. Involved in several processes, including cellular response to lead ion; response to herbicide; and response to vitamin. Located in cytosol and extracellular space. Used to study anemia and hemochromatosis. Biomarker of acute kidney failure; hypothyroidism; liver cirrhosis; status epilepticus; and visual epilepsy. Human ortholog(s) of this gene implicated in porphyria cutanea tarda and sickle cell anemia. Orthologous to human ALAD (aminolevulinate dehydratase). [provided by Alliance of Genome Resources, Apr 2022]

Alad Products(1)

mRNA	Protein	Name
NM_012899.2	NP_037031.1	delta-aminolevulinic acid dehydratase

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables porphobilinogen synthase activity	IDA IDA: Inferred from direct assay	19095280	RGD
enables proteasome core complex binding	IDA IDA: Inferred from direct assay	21640720	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in cellular response to lead ion	IEP IEP: Inferred from expression pattern	16566714	RGD
involved in heme biosynthetic process	IDA IDA: Inferred from direct assay	1764448	RGD
involved in response to activity	IEP IEP: Inferred from expression pattern	12171438	RGD
involved in response to aluminum ion	IEP IEP: Inferred from expression pattern	518129	RGD
involved in response to amino acid	IEP IEP: Inferred from expression pattern	8295845	RGD
involved in response to arsenic-containing substance	IDA IDA: Inferred from direct assay	17086449	RGD
involved in response to arsenic-containing substance	IEP IEP: Inferred from expression pattern	19966145	RGD
involved in response to cadmium ion	IDA IDA: Inferred from direct assay	7896311	RGD
involved in response to cadmium ion	IEP IEP: Inferred from expression pattern	20019094	RGD
involved in response to cobalt ion	IEP IEP: Inferred from expression pattern	826600	RGD
involved in response to ethanol	IDA IDA: Inferred from direct assay	2394940	RGD
involved in response to fatty acid	IEP IEP: Inferred from expression pattern	20026167	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	12596873	RGD
involved in response to herbicide	IEP IEP: Inferred from expression pattern	12180188	RGD
involved in response to hormone	IEP IEP: Inferred from expression pattern	9468112	RGD
involved in response to hypoxia	IEP IEP: Inferred from expression pattern	3697363	RGD
involved in response to ionizing radiation	IEP IEP: Inferred from expression pattern	17916974	RGD
involved in response to iron ion	IEP IEP: Inferred from expression pattern	14598909	RGD
involved in response to lead ion	IEP IEP: Inferred from expression pattern	16597373	RGD
involved in response to lipopolysaccharide	IEP IEP: Inferred from expression pattern	19344711	RGD
involved in response to mercury ion	IEP IEP: Inferred from expression pattern	17881112	RGD
involved in response to metal ion	IDA IDA: Inferred from direct assay	15302091	RGD
involved in response to metal ion	IEP IEP: Inferred from expression pattern	3629603	RGD
involved in response to methylmercury	IEP IEP: Inferred from expression pattern	19874286	RGD
involved in response to nutrient	IDA IDA: Inferred from direct assay	2394940	RGD
involved in response to nutrient levels	IEP IEP: Inferred from expression pattern	8000239	RGD
involved in response to organic cyclic compound	IEP IEP: Inferred from expression pattern	19647414	RGD
involved in response to oxidative stress	IEP IEP: Inferred from expression pattern	17916976	RGD
involved in response to platinum ion	IEP IEP: Inferred from expression pattern	925603	RGD
involved in response to selenium ion	IEP IEP: Inferred from expression pattern	15721883	RGD
involved in response to toxic substance	IEP IEP: Inferred from expression pattern	20517888	RGD
involved in response to vitamin	IEP IEP: Inferred from expression pattern	9559098	RGD
involved in response to vitamin B1	IEP IEP: Inferred from expression pattern	20088549	RGD
involved in response to vitamin E	IEP IEP: Inferred from expression pattern	17572058	RGD
involved in response to xenobiotic stimulus	IDA IDA: Inferred from direct assay	8070841	RGD
involved in response to xenobiotic stimulus	IEP IEP: Inferred from expression pattern	19486337	RGD
involved in response to zinc ion	IDA IDA: Inferred from direct assay	3987589	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	19111884	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

delta-aminolevulinic acid dehydratase

ALADH	aminolevulinate, delta-, dehydratase
delta - aminolevulinic acid dehydratase	porphobilinogen synthase

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS00553	ALAD Human Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS17104	Alad Mouse Pre-designed siRNA Set A	Pre-designed Set	/	Unkown
HY-RS23548	Alad Rat Pre-designed siRNA Set A	Pre-designed Set	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Alad	NCBI	NCBI:210
Macaca fascicularis	Alad	NCBI	NCBI:102130527
Mus musculus	Alad	NCBI	NCBI:17025

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