Grk3 - G protein-coupled receptor kinase 3 Gene

Rattus norvegicus

Also known as Adrbk2

Gene ID: 25372 | Gene type: protein coding

About Grk3

Summary

Enables D1 Dopamine Receptor binding activity; G protein-coupled receptor kinase activity; and beta-adrenergic receptor kinase activity. Involved in several processes, including cellular protein metabolic process; desensitization of G protein-coupled receptor signaling pathway; and response to morphine. Located in several cellular components, including Z disc; dendrite; and sperm midpiece. Biomarker of Parkinson's disease; hypertension; and hypothyroidism. Orthologous to human GRK3 (G protein-coupled receptor kinase 3). [provided by Alliance of Genome Resources, Apr 2022]

Grk3 Products(1)

mRNA	Protein	Name
NM_012897.3	NP_037029.2	beta-adrenergic receptor kinase 2

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables D1 dopamine receptor binding	IPI IPI: Inferred from physical interaction	20837135	RGD
enables G protein-coupled receptor kinase activity	IDA IDA: Inferred from direct assay	1403099	RGD
enables beta-adrenergic receptor kinase activity	IDA IDA: Inferred from direct assay	1403099	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in G protein-coupled receptor signaling pathway	IEP IEP: Inferred from expression pattern	29081032	RGD
involved in desensitization of G protein-coupled receptor signaling pathway	IDA IDA: Inferred from direct assay	20837135	RGD
involved in desensitization of G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	8381966	RGD
involved in inositol phosphate metabolic process	IMP IMP: Inferred from mutant phenotype	17573483	RGD
involved in intracellular protein transport	IMP IMP: Inferred from mutant phenotype	8276821	RGD
involved in positive regulation of protein phosphorylation	IDA IDA: Inferred from direct assay	20837135	RGD
involved in protein phosphorylation	IDA IDA: Inferred from direct assay	1403099	RGD
involved in protein phosphorylation	IMP IMP: Inferred from mutant phenotype	8381966	RGD
involved in rhodopsin metabolic process	IMP IMP: Inferred from mutant phenotype	17573483	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in Z disc	IDA IDA: Inferred from direct assay	15584034	RGD
located in axon	IDA IDA: Inferred from direct assay	1403099	RGD
located in dendrite terminus	IDA IDA: Inferred from direct assay	16374707	RGD
located in dendritic shaft	IDA IDA: Inferred from direct assay	1403099	RGD
located in dendritic spine	IDA IDA: Inferred from direct assay	1403099	RGD
is active in glutamatergic synapse	IDA IDA: Inferred from direct assay	1403099	RGD
located in perinuclear region of cytoplasm	IDA IDA: Inferred from direct assay	20837135	RGD
is active in postsynaptic density	IDA IDA: Inferred from direct assay	1403099	RGD
is active in presynapse	IDA IDA: Inferred from direct assay	1403099	RGD
located in sperm midpiece	IDA IDA: Inferred from direct assay	8529092	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

beta-adrenergic receptor kinase 2

adrenergic receptor kinase, beta 2 (G-protein-linked receptor kinase)	adrenergic, beta, receptor kinase 2
beta ARK2	beta-ARK-2

Related Agents

Pre-clinical Phase

Bioactive Molecules (4)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-103045A	CMPD101 hydrochloride	Inhibitor	/	Unkown
HY-RS05814	GRK3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS20749	Grk3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS27261	Grk3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grk3	NCBI	NCBI:157

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