Sftpd - surfactant protein D Gene

Rattus norvegicus

Also known as SPD; SP-D

Gene ID: 25350 | Gene type: protein coding

About Sftpd

Summary

Enables identical protein binding activity; lipopolysaccharide binding activity; and monosaccharide binding activity. Involved in several processes, including negative regulation of interleukin-2 production; opsonization; and regulation of phagocytosis. Located in extracellular space; multivesicular body; and rough endoplasmic reticulum. Biomarker of Coronavirus infectious disease; asthma; Bacterial pneumonia; lung disease; and newborn respiratory distress syndrome. Human ortholog(s) of this gene implicated in asthma; lung disease (multiple); respiratory syncytial virus infectious disease; and rhinitis. Orthologous to human SFTPD (surfactant protein D). [provided by Alliance of Genome Resources, Apr 2022]

Sftpd Products(1)

mRNA	Protein	Name
NM_012878.3	NP_037010.1	pulmonary surfactant-associated protein D precursor

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables identical protein binding	IDA IDA: Inferred from direct assay	19017984	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	19007302	RGD
enables lipopolysaccharide binding	IDA IDA: Inferred from direct assay	18092821	RGD
enables monosaccharide binding	IDA IDA: Inferred from direct assay	18092821	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in negative regulation of T cell proliferation	IDA IDA: Inferred from direct assay	9794387	RGD
involved in negative regulation of interleukin-2 production	IDA IDA: Inferred from direct assay	9794387	RGD
involved in negative regulation of phagocytosis	IDA IDA: Inferred from direct assay	12654779	RGD
involved in opsonization	IDA IDA: Inferred from direct assay	19017984	RGD
involved in positive regulation of phagocytosis	IDA IDA: Inferred from direct assay	15591410	RGD
involved in response to glucocorticoid	IEP IEP: Inferred from expression pattern	8292379	RGD
involved in response to growth factor	IEP IEP: Inferred from expression pattern	11076805	RGD
involved in response to hyperoxia	IEP IEP: Inferred from expression pattern	11472975	RGD
involved in surfactant homeostasis	IDA IDA: Inferred from direct assay	9201966	RGD
involved in surfactant homeostasis	IMP IMP: Inferred from mutant phenotype	10666121	RGD

Cellular Component GO Annotation	Evidence	Reference	Source
located in extracellular space	IDA IDA: Inferred from direct assay	11472975	RGD
located in multivesicular body	IDA IDA: Inferred from direct assay	16187065	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

pulmonary surfactant-associated protein D

CP4	PSP-D
lung surfactant protein D	pulmonary surfactant protein D
surfactant associated protein D	surfactant, pulmonary-associated protein D

Related Agents

Pre-clinical Phase

Bioactive Molecules (3)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS12784	SFTPD Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS17774	Sftpd Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS24241	Sftpd Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Sftpd	NCBI	NCBI:6441
Mus musculus	Sftpd	NCBI	NCBI:20390
Macaca mulatta	Sftpd	NCBI	NCBI:678657

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