Npr3 - natriuretic peptide receptor 3 Gene

Rattus norvegicus

Also known as NPRC; ANP-CR

Gene ID: 25339 | Gene type: protein coding

About Npr3

Summary

Enables identical protein binding activity; peptide hormone binding activity; and peptide receptor activity. Involved in several processes, including G protein-coupled receptor signaling pathway; negative regulation of Adenylate Cyclase activity; and positive regulation of nitric-oxide synthase activity. Located in membrane. Biomarker of diabetic retinopathy. Human ortholog(s) of this gene implicated in hypertension. Orthologous to human NPR3 (natriuretic peptide receptor 3). [provided by Alliance of Genome Resources, Apr 2022]

Npr3 Products(1)

mRNA	Protein	Name
NM_012868.1	NP_037000.1	atrial natriuretic peptide receptor 3 precursor

Gene Ontology

Molecular Function
Biological Process

Molecular Function GO Annotation	Evidence	Reference	Source
enables G protein-coupled peptide receptor activity	IDA IDA: Inferred from direct assay	9843699	RGD
enables identical protein binding	IPI IPI: Inferred from physical interaction	8702617	RGD
enables natriuretic peptide receptor activity	IDA IDA: Inferred from direct assay	9843699	RGD
enables natriuretic peptide receptor activity	IMP IMP: Inferred from mutant phenotype	7911802	RGD
enables peptide hormone binding	IDA IDA: Inferred from direct assay	8702617	RGD

Biological Process GO Annotation	Evidence	Reference	Source
involved in adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	12676657	RGD
involved in negative regulation of adenylate cyclase activity	IDA IDA: Inferred from direct assay	8702617	RGD
involved in negative regulation of smooth muscle cell proliferation	IMP IMP: Inferred from mutant phenotype	21457229	RGD
involved in phospholipase C-activating G protein-coupled receptor signaling pathway	IMP IMP: Inferred from mutant phenotype	15044621	RGD
involved in positive regulation of nitric-oxide synthase activity	IDA IDA: Inferred from direct assay	9843699	RGD
involved in positive regulation of pancreatic juice secretion	IMP IMP: Inferred from mutant phenotype	12829435	RGD
involved in regulation of blood pressure	IMP IMP: Inferred from mutant phenotype	15337698	RGD
involved in vasodilation	IMP IMP: Inferred from mutant phenotype	17391657	RGD

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

atrial natriuretic peptide receptor 3

ANP-C	ANPR-C
ANPRC	Atrial natriuretic peptide clearence receptor 3
NPR-C	atrial natriuretic peptide C-type receptor
atrial natriuretic peptide clearance receptor	atrial natriuretic peptide receptor type C
natriuretic peptide receptor C/guanylate c

Related Agents

Pre-clinical Phase

Bioactive Molecules (6)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-P1419	AP 811	Antagonist	98.07%	Unkown
HY-P1419A	AP 811 acetate	Antagonist	/	Unkown
HY-RS09499	NPR3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS09501	NPRL3 Human Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS19149	Npr3 Mouse Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown
HY-RS25640	Npr3 Rat Pre-designed siRNA Set A	Pre-designed Sets	/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Npr3	NCBI	NCBI:4883

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