2. Gene
  3. Ms4a2 - membrane spanning 4-domains A2 Gene

Ms4a2 - membrane spanning 4-domains A2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as FCIGA; Ms4a1; Fcer1b

Gene ID: 25316 | Gene type: protein coding

About Ms4a2

Summary

Enables SH2 domain binding activity; phosphoprotein binding activity; and protein kinase binding activity. Contributes to IgE receptor activity. Involved in several processes, including activation of Phospholipase C activity; positive regulation of mast cell degranulation; and protein kinase C-activating G protein-coupled receptor signaling pathway. Located in endosome and membrane raft. Is integral component of plasma membrane. Human ortholog(s) of this gene implicated in asthma; atopic dermatitis; and rhinitis. Orthologous to human MS4A2 (membrane spanning 4-domains A2). [provided by Alliance of Genome Resources, Apr 2022]

Ms4a2 Products(1)

mRNA Protein Name
NM_012845.1 NP_036977.1 high affinity immunoglobulin epsilon receptor subunit beta
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables SH2 domain binding IDA
IDA: Inferred from direct assay
8910399 RGD
enables phosphoprotein binding IPI
IPI: Inferred from physical interaction
8910399 RGD
enables protein kinase binding IPI
IPI: Inferred from physical interaction
16177098 RGD
Biological Process GO Annotation Evidence Reference Source
involved in positive regulation of mast cell degranulation IMP
IMP: Inferred from mutant phenotype
16177098 RGD
involved in regulation of release of sequestered calcium ion into cytosol IGI
IGI: Inferred from genetic interaction
16177098 RGD
Cellular Component GO Annotation Evidence Reference Source
located in endosome IDA
IDA: Inferred from direct assay
11101638 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

high affinity immunoglobulin epsilon receptor subunit beta

IgE Fc receptor subunit beta

Membrane-spanning 4-domains, subfamily A, member 1

beta polypeptide)

fc epsilon receptor I beta-chain

fcERI

membrane-spanning 4-domains, subfamily A, member 2 (Fc fragment of IgE, high affinity I, receptor for

membrane-s

Related Agents

Pre-clinical Phase
Bioactive Molecules (4)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS08697 Ms4a1 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS08700 MS4A2 Human Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS18183 Ms4a2 Mouse Pre-designed siRNA Set A Pre-designed Set / Unkown
HY-RS24657 Ms4a2 Rat Pre-designed siRNA Set A Pre-designed Set / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ms4a2 NCBI NCBI:2206
Macaca fascicularis Ms4a2 NCBI NCBI:102127416
Canis lupus familiaris Ms4a2 NCBI
Mus musculus Ms4a2 NCBI NCBI:14126