2. Gene
  3. Ephx1 - epoxide hydrolase 1 Gene

Ephx1 - epoxide hydrolase 1 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as mEH; MEH8

Gene ID: 25315 | Gene type: protein coding

About Ephx1

Summary

Enables cis-stilbene-oxide hydrolase activity; enzyme binding activity; and Epoxide Hydrolase activity. Involved in several processes, including cellular response to glucocorticoid stimulus; diol biosynthetic process; and liver development. Located in intracellular membrane-bounded organelle and plasma membrane. Human ortholog(s) of this gene implicated in several diseases, including Leber hereditary optic neuropathy; anemia (multiple); hematologic Cancer (multiple); respiratory system disease (multiple); and toxic encephalopathy. Orthologous to human EPHX1 (Epoxide Hydrolase 1). [provided by Alliance of Genome Resources, Apr 2022]

Ephx1 Products(2)

mRNA Protein Name
NM_001034090.3 NP_001029262.1 epoxide hydrolase 1 precursor
NM_012844.3 NP_036976.2 epoxide hydrolase 1 precursor
Gene Ontology
  • Molecular Function
  • Biological Process
  • Cellular Component
Molecular Function GO Annotation Evidence Reference Source
enables cis-stilbene-oxide hydrolase activity IMP
IMP: Inferred from mutant phenotype
9854022 RGD
enables enzyme binding IPI
IPI: Inferred from physical interaction
10891369 RGD
enables epoxide hydrolase activity IDA
IDA: Inferred from direct assay
8313504 RGD
enables epoxide hydrolase activity IMP
IMP: Inferred from mutant phenotype
9854022 RGD
Biological Process GO Annotation Evidence Reference Source
involved in cellular response to glucocorticoid stimulus IEP
IEP: Inferred from expression pattern
2350182 RGD
involved in diol biosynthetic process IDA
IDA: Inferred from direct assay
2507189 RGD
involved in epoxide metabolic process IDA
IDA: Inferred from direct assay
9854022 RGD
involved in liver development IEP
IEP: Inferred from expression pattern
2469391 RGD
Cellular Component GO Annotation Evidence Reference Source
located in intracellular membrane-bounded organelle IDA
IDA: Inferred from direct assay
9245728 RGD
located in membrane IDA
IDA: Inferred from direct assay
9245728 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

epoxide hydrolase 1

epoxide hydratase

epoxide hydrolase 1 (microsomal xenobiotic hydrolase)

epoxide hydrolase 1, microsomal (xenobiotic)

liver microsomal xenobiotic epoxide hydrolase

microsomal epoxide hydrolase

Related Agents

Pre-clinical Phase
Bioactive Molecules (3)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-RS04438 EPHX1 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS18662 Ephx1 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS25148 Ephx1 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Ephx1 NCBI NCBI:2052