Grhl2 - grainyhead like transcription factor 2 Gene

Mus musculus

Also known as BOM; clft3; Tcfcp2l3; 0610015A08Rik

Gene ID: 252973 | Gene type: protein coding

About Grhl2

Summary

Enables DNA-binding transcription factor activity; chromatin binding activity; and intronic transcription regulatory region sequence-specific DNA binding activity. Involved in several processes, including epithelial cell differentiation; neural tube closure; and positive regulation of transcription by RNA polymerase II. Acts upstream of or within several processes, including animal organ development; embryonic morphogenesis; and face development. Located in nucleus. Is expressed in several structures, including alimentary system; genitourinary system; integumental system; respiratory system; and sensory organ. Human ortholog(s) of this gene implicated in autosomal dominant nonsyndromic deafness 28 and posterior polymorphous corneal dystrophy 4. Orthologous to human GRHL2 (grainyhead like transcription factor 2). [provided by Alliance of Genome Resources, Apr 2022]

Grhl2 Products(1)

mRNA	Protein	Name
NM_026496.4	NP_080772.2	grainyhead-like protein 2 homolog

Gene Ontology

Molecular Function
Biological Process
Cellular Component

Molecular Function GO Annotation	Evidence	Reference	Source
enables DNA-binding transcription factor activity	IDA IDA: Inferred from direct assay	20978075	MGI
enables chromatin binding	IDA IDA: Inferred from direct assay	25758223	MGI
enables intronic transcription regulatory region sequence-specific DNA binding	IDA IDA: Inferred from direct assay	20978075	MGI
enables sequence-specific DNA binding	IDA IDA: Inferred from direct assay	21081122	MGI

Biological Process GO Annotation	Evidence	Reference	Source
acts upstream of or within anterior neural tube closure	IMP IMP: Inferred from mutant phenotype	21515572	MGI
acts upstream of or within brain development	IMP IMP: Inferred from mutant phenotype	21377456	MGI
acts upstream of or within camera-type eye development	IMP IMP: Inferred from mutant phenotype	21377456	MGI
acts upstream of or within cardiac ventricle morphogenesis	IMP IMP: Inferred from mutant phenotype	21377456	MGI
acts upstream of or within embryonic cranial skeleton morphogenesis	IMP IMP: Inferred from mutant phenotype	21377456	MGI
acts upstream of or within embryonic digit morphogenesis	IMP IMP: Inferred from mutant phenotype	21377456	MGI
acts upstream of or within embryonic organ development	IMP IMP: Inferred from mutant phenotype	21377456	MGI
involved in epidermis development	IMP IMP: Inferred from mutant phenotype	21081122	MGI
involved in epithelial cell morphogenesis	IMP IMP: Inferred from mutant phenotype	22696678	MGI
acts upstream of or within epithelial cell morphogenesis involved in placental branching	IMP IMP: Inferred from mutant phenotype	25758223	MGI
involved in epithelium migration	IMP IMP: Inferred from mutant phenotype	22955271	MGI
acts upstream of or within face development	IMP IMP: Inferred from mutant phenotype	21377456	MGI
acts upstream of or within in utero embryonic development	IMP IMP: Inferred from mutant phenotype	21262862	MGI
involved in lung epithelial cell differentiation	IMP IMP: Inferred from mutant phenotype	22955271	MGI
acts upstream of or within lung lobe morphogenesis	IMP IMP: Inferred from mutant phenotype	21377456	MGI
acts upstream of or within multicellular organism growth	IMP IMP: Inferred from mutant phenotype	21377456	MGI
acts upstream of or within neural tube closure	IMP IMP: Inferred from mutant phenotype	21262862	MGI
involved in neural tube closure	IMP IMP: Inferred from mutant phenotype	20654612	MGI
acts upstream of or within neural tube development	IMP IMP: Inferred from mutant phenotype	21377456	MGI
involved in positive regulation of DNA-templated transcription	IMP IMP: Inferred from mutant phenotype	22955271	MGI
involved in positive regulation of transcription by RNA polymerase II	IDA IDA: Inferred from direct assay	20978075	MGI
acts upstream of or within regulation of gene expression	IMP IMP: Inferred from mutant phenotype	21377456	MGI
acts upstream of or within respiratory tube development	IMP IMP: Inferred from mutant phenotype	21377456	MGI

Cellular Component GO Annotation	Evidence	Reference	Source
located in nucleus	IDA IDA: Inferred from direct assay	22955271	MGI

EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern

Protein Preferred Names

Protein Names

grainyhead-like protein 2 homolog

brother of mammalian grainyhead	grainyhead like 2
grainyhead-like 2	grainyheadlike
transcription factor CP2-like 3

Related Agents

Pre-clinical Phase

Bioactive Molecules (1)

Cat. No.	Product Name	Effect	Purity	Rare Diseases
HY-RS27463	Grhl2 Rat Pre-designed siRNA Set A		/	Unkown

Orthologs Information

Species	Symbol	Source	ID
Homo sapiens	Grhl2	NCBI	NCBI:79977

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