2. Gene
  3. Dgat2 - diacylglycerol O-acyltransferase 2 Gene

Dgat2 - diacylglycerol O-acyltransferase 2 Gene

  • Gene
  • Protein
  • Agent
  • Ortholog
Rattus norvegicus

Also known as ARAT

Gene ID: 252900 | Gene type: protein coding

About Dgat2

Summary

Enables diacylglycerol O-acyltransferase activity. Involved in several processes, including bile acid signaling pathway; positive regulation of gluconeogenesis; and regulation of lipid metabolic process. Located in intracellular membrane-bounded organelle. Used to study fatty liver disease. Biomarker of chronic kidney disease; non-alcoholic fatty liver disease; and premature menopause. Human ortholog(s) of this gene implicated in non-alcoholic fatty liver disease. Orthologous to human DGAT2 (diacylglycerol O-acyltransferase 2). [provided by Alliance of Genome Resources, Apr 2022]

Dgat2 Products(1)

mRNA Protein Name
NM_001012345.1 NP_001012345.1 diacylglycerol O-acyltransferase 2
Gene Ontology
  • Molecular Function
  • Biological Process
Molecular Function GO Annotation Evidence Reference Source
enables diacylglycerol O-acyltransferase activity IDA
IDA: Inferred from direct assay
12235188 RGD
Biological Process GO Annotation Evidence Reference Source
involved in diacylglycerol metabolic process IMP
IMP: Inferred from mutant phenotype
17526931 RGD
involved in negative regulation of fatty acid oxidation IMP
IMP: Inferred from mutant phenotype
17526931 RGD
involved in positive regulation of gluconeogenesis IMP
IMP: Inferred from mutant phenotype
17526931 RGD
involved in positive regulation of triglyceride biosynthetic process IMP
IMP: Inferred from mutant phenotype
17526931 RGD
involved in regulation of cholesterol metabolic process IMP
IMP: Inferred from mutant phenotype
17526931 RGD
involved in regulation of lipoprotein metabolic process IMP
IMP: Inferred from mutant phenotype
17526931 RGD
involved in response to nutrient IEP
IEP: Inferred from expression pattern
26394137 RGD
EXP: Inferred from Experiment IDA: Inferred from direct assay IPI: Inferred from physical interaction IMP: Inferred from mutant phenotype IGI: Inferred from genetic interaction IEP: Inferred from expression pattern
Protein Preferred Names Protein Names

diacylglycerol O-acyltransferase 2

acyl-CoA retinol O-fatty-acyltransferase

diglyceride acyltransferase 2

retinol O-fatty-acyltransferase

Related Agents

Pre-clinical Phase
Bioactive Molecules (16)
Cat. No. Product Name Effect
Purity Rare Diseases
HY-108341A PF-06424439 methanesulfonate Inhibitor 99.85% Unkown
HY-32219 T863 Inhibitor 99.83% Unkown
HY-108341 PF-06424439 Inhibitor 99.89% Unkown
HY-110381 JNJ-DGAT2-A Inhibitor 98.26% Unkown
HY-156259 PF-07202954 Inhibitor 98.82% Unkown
HY-159698A IONIS-DGAT 2Rx sodium Inhibitor 96.10% Unkown
HY-23199 H2-003 Inhibitor 99.53% Unkown
HY-118386 H2-005 / Unkown
HY-145624 Obeversen Inhibitor / Unkown
HY-159698 IONIS-DGAT 2Rx Inhibitor / Unkown
HY-162854 Diacylglycerol acyltransferase inhibitor-2 Inhibitor / Unkown
HY-162978 DGAT2-IN-3 Inhibitor / Unkown
HY-RS03711 DGAT2 Human Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-169499 (R)-2-(3-(2-Ethoxyphenoxy)piperidin-1-yl)pyrimidine-5-carboxylic Acid / Unkown
HY-RS16657 Dgat2 Mouse Pre-designed siRNA Set A Pre-designed Sets / Unkown
HY-RS23092 Dgat2 Rat Pre-designed siRNA Set A Pre-designed Sets / Unkown

Orthologs Information

Species Symbol Source ID
Homo sapiens Dgat2 NCBI NCBI:84649